Probing the conformational change of Escherichia coli undecaprenyl pyrophosphate synthase during catalysis using an inhibitor and tryptophan mutants.

Substrate and product specificities of cis-type undecaprenyl pyrophosphate synthase.

Chen, AP

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Roles of Amino Acids in the Escherichia coli Octaprenyl Diphosphate Synthase Active Site Probed by Structure-Guided Site-Directed Mutagenesis.

Chang, KM

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Catalytic mechanism revealed by the crystal structure of undecaprenyl pyrophosphate synthase in complex with sulfate, magnesium, and triton.

Chang, SY

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Mechanism of product chain length determination and the role of a flexible loop in Escherichia coli undecaprenyl-pyrophosphate synthase catalysis.

Ko, TP

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Substrate binding mode and reaction mechanism of undecaprenyl pyrophosphate synthase deduced from crystallographic studies

Chang, SY

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

A novel substrate binding mode revealed by the site-directed mutagenesis studies of E. coli octaprenyl pyrophosphate synthase

Kuo, CJ

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Anthranilic Acid Inhibitors of Undecaprenyl Pyrophosphate Synthase (UppS), an Essential Enzyme for Bacterial Cell Wall Biosynthesis

Jukič, Marko
Rožman, Kaja
Sova, Matej
Barreteau, Hélène
Gobec, Stanislav

January 2018

We report the successful implementation of virtual screening in the discovery of new inhibitors of u...

Applying Molecular Dynamics Simulations to Identify Rarely Sampled Ligand-bound

Conformational States Of Undecaprenyl
Pyrophosphate Synthase
An Antibacterial Target
William Sinko
César De Oliveira
Sarah Williams
Adam Van Wynsberghe
Jacob D. Durrant
Rong Cao
J. Andrew Mccammon

August 2016

Undecaprenyl pyrophosphate synthase is a cis-pre-nyltransferase enzyme, which is required for cell w...

Biophysical Investigation of the Mode of Inhibition of Tetramic Acids, the Allosteric Inhibitors of Undecaprenyl Pyrophosphate Synthase

Lac V. Lee (1271397)
Brian Granda (1271394)
Karl Dean (1271388)
Jianshi Tao (1271412)
Eugene Liu (1271409)
Rui Zhang (13940)
Stefan Peukert (1271403)
Sompong Wattanasin (1271406)
Xiaoling Xie (552286)
Neil S. Ryder (1271400)
Ruben Tommasi (1271391)
Gejing Deng (308332)

December 2015

Undecaprenyl pyrophosphate synthase (UPPS) catalyzes the consecutive condensation of eight molecules...

Structural and functional characterization of enzymes central to bacterial carrier lipid synthesis and recycling

Workman, Sean Douglas

January 2020

In bacteria, the carrier lipid undecaprenyl phosphate (C₅₅P) is used as a scaffold for the synthesis...

Structure-based inhibitors exhibited differential activities against H. pylori and E. coli undecaprenyl pyrophosphate synthases

Kuo, CJ

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases.

Kuo, CJ

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Product distribution and pre-steady-state kinetic analysis of Escherichia coli undecaprenyl pyrophosphate synthase reaction

Pan, JJ

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

DOI: 10.1021/bi100523c Biophysical Investigation of the Mode of Inhibition of Tetramic Acids, the Allosteric

Inhibitors Undecaprenyl
Pyrophosphate Synthase
Lac V. Lee
Brian Gr
Karl Dean
Jianshi Tao
Eugene Liu
Rui Zhang
Stefan Peukert
Sompong Wattanasin
Xiaoling Xie
Neil S. Ryder
Ruben Tommasi
Gejing Deng

January 2010

ABSTRACT: Undecaprenyl pyrophosphate synthase (UPPS) catalyzes the consecutive condensation of eight...

Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms.

Han, X

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Substrate and product specificities of cis-type undecaprenyl pyrophosphate synthase.

Chen, AP

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Roles of Amino Acids in the Escherichia coli Octaprenyl Diphosphate Synthase Active Site Probed by Structure-Guided Site-Directed Mutagenesis.

Chang, KM

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Catalytic mechanism revealed by the crystal structure of undecaprenyl pyrophosphate synthase in complex with sulfate, magnesium, and triton.

Chang, SY

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Mechanism of product chain length determination and the role of a flexible loop in Escherichia coli undecaprenyl-pyrophosphate synthase catalysis.

Ko, TP

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Substrate binding mode and reaction mechanism of undecaprenyl pyrophosphate synthase deduced from crystallographic studies

Chang, SY

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

A novel substrate binding mode revealed by the site-directed mutagenesis studies of E. coli octaprenyl pyrophosphate synthase

Kuo, CJ

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Anthranilic Acid Inhibitors of Undecaprenyl Pyrophosphate Synthase (UppS), an Essential Enzyme for Bacterial Cell Wall Biosynthesis

Jukič, Marko
Rožman, Kaja
Sova, Matej
Barreteau, Hélène
Gobec, Stanislav

January 2018

We report the successful implementation of virtual screening in the discovery of new inhibitors of u...

Applying Molecular Dynamics Simulations to Identify Rarely Sampled Ligand-bound

Conformational States Of Undecaprenyl
Pyrophosphate Synthase
An Antibacterial Target
William Sinko
César De Oliveira
Sarah Williams
Adam Van Wynsberghe
Jacob D. Durrant
Rong Cao
J. Andrew Mccammon

August 2016

Undecaprenyl pyrophosphate synthase is a cis-pre-nyltransferase enzyme, which is required for cell w...

Biophysical Investigation of the Mode of Inhibition of Tetramic Acids, the Allosteric Inhibitors of Undecaprenyl Pyrophosphate Synthase

Lac V. Lee (1271397)
Brian Granda (1271394)
Karl Dean (1271388)
Jianshi Tao (1271412)
Eugene Liu (1271409)
Rui Zhang (13940)
Stefan Peukert (1271403)
Sompong Wattanasin (1271406)
Xiaoling Xie (552286)
Neil S. Ryder (1271400)
Ruben Tommasi (1271391)
Gejing Deng (308332)

December 2015

Undecaprenyl pyrophosphate synthase (UPPS) catalyzes the consecutive condensation of eight molecules...

Structural and functional characterization of enzymes central to bacterial carrier lipid synthesis and recycling

Workman, Sean Douglas

January 2020

In bacteria, the carrier lipid undecaprenyl phosphate (C₅₅P) is used as a scaffold for the synthesis...

Structure-based inhibitors exhibited differential activities against H. pylori and E. coli undecaprenyl pyrophosphate synthases

Kuo, CJ

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases.

Kuo, CJ

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Product distribution and pre-steady-state kinetic analysis of Escherichia coli undecaprenyl pyrophosphate synthase reaction

Pan, JJ

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

DOI: 10.1021/bi100523c Biophysical Investigation of the Mode of Inhibition of Tetramic Acids, the Allosteric

Inhibitors Undecaprenyl
Pyrophosphate Synthase
Lac V. Lee
Brian Gr
Karl Dean
Jianshi Tao
Eugene Liu
Rui Zhang
Stefan Peukert
Sompong Wattanasin
Xiaoling Xie
Neil S. Ryder
Ruben Tommasi
Gejing Deng

January 2010

ABSTRACT: Undecaprenyl pyrophosphate synthase (UPPS) catalyzes the consecutive condensation of eight...

Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms.

Han, X

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Substrate and product specificities of cis-type undecaprenyl pyrophosphate synthase.

Chen, AP

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Roles of Amino Acids in the Escherichia coli Octaprenyl Diphosphate Synthase Active Site Probed by Structure-Guided Site-Directed Mutagenesis.

Chang, KM

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Catalytic mechanism revealed by the crystal structure of undecaprenyl pyrophosphate synthase in complex with sulfate, magnesium, and triton.

Chang, SY

[[sponsorship]]生物化學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Ga...

Probing the conformational change of Escherichia coli undecaprenyl pyrophosphate synthase during catalysis using an inhibitor and tryptophan mutants.

Abstract

Extracted data

Probing the conformational change of Escherichia coli undecaprenyl pyrophosphate synthase during catalysis using an inhibitor and tryptophan mutants.

Abstract

Extracted data

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