Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease
- Besusso D.
- Schellino R.
- Boido M.
- Belloli S.
- Parolisi R.
- Conforti P.
- Faedo A.
- Cernigoj M.
- Campus I.
- Laporta A.
- Bocchi V. D.
- Murtaj V.
- Parmar M.
- Spaiardi P.
- Talpo F.
- Maniezzi C.
- Toselli M. G.
- Biella G.
- Moresco R. M.
- Vercelli A.
- Buffo A.
- Cattaneo E.
Publication date
January 2020
DOIAbstract
In this article, Cattaneo, Buffo, Besusso, and colleagues investigate the short-term in vivo therapeutic benefits of a cell replacement approach for Huntington disease (HD) using hESC-derived MSN progenitors. Upon intra-striatal transplantation in a neurotoxin model of HD, donor cells survive and mature in the host tissue reaching appropriate target regions, establishing synaptic contacts and mitigating lesion-dependent sensorimotor deficits
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