Achiral SFC for Purification of Pharmaceuticals

Wolf, Thomas
Meishammer, Aldo
Patissier, Celine
Reck, Marcel
Valente, Claudio
Reilly, John

Publication date

January 2021

Publisher

International Labmate

Abstract

With large quantities of small scale (<1000mg) separations typically being needed to be purified and evaluated for discovery in-vitro and in-vivo testing regimes, a chromatographic purification technique needs to be easily integrated into discovery chemistry laboratories and highly reproducible. HPLC has been generally accepted as the main technique of choice for analysis and purification, utilizing either normal phase or reverse phase conditions, with reverse phase being the generally accepted as a high throughput approach to purify small scale drug discovery products At Novartis, the integration of supercritical fluid chromatography (SFC) has several advantages such as faster run times due to lower viscosity, short equilibration times, r...

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Achiral SFC for Purification of Pharmaceuticals

Abstract

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Achiral SFC for Purification of Pharmaceuticals

Abstract

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