Design of High-Performance Fiber-optic Sensor Systems for Sensitive and Selective Detection of Ammonia and Creatinine Urinary Biomarkers

北九州市立大学博士(工学)In this Ph.D. thesis, we designed an optical fiber sensor modified with nano-thin films and evaluated its characteristics for the purpose of highly sensitive and selective detection of two important renal biomarkers, ammonia and creatinine. Ammonia and creatinine are important urinary metabolites in the physiological and pathological aspects associated with kidney disease. Accurate detection of these metabolites from urine or exhaled breath is an importance topic in the medical field as a non-invasive diagnostic method. On the other hand, detection of these compounds in exhaled breath or urine samples are generally troublesome due to their very low concentrations, the complexity of the coexisting (matrix) components contained in the samples, and the high humidity. Sophisticated analyzers are expensive, costly, and time consuming, making it difficult to spread as a general-purpose technology. In order to solve these problems, in this thesis, we researched and developed an optical detection system that can easily and quickly detect the renal biomarker, using optical fiber.doctoral thesi