Molecular tracing of SARS-CoV-2 in Italy in the first three months of the epidemic
- Lai A.
- Bergna A.
- Caucci S.
- Clementi N.
- Vicenti I.
- Dragoni F.
- Cattelan A. M.
- Menzo S.
- Pan A.
- Callegaro A.
- Tagliabracci A.
- Caruso A.
- Caccuri F.
- Ronchiadin S.
- Balotta C.
- Zazzi M.
- Vaccher E.
- Clementi M.
- Galli M.
- Zehender G.
- F Alessandrini
- M Andreoni
- G Antonelli
- S Babudieri
- P Bagnarelli
- S Bonora
- B Bruzzone
- G Brindicci
- P Carrer
- F Ceccherini
- M Codeluppi
- A Coluccello
- N Coppola
- MG Cusi
- C Della Ventura
- Laura Di Sante
- S Di Giambenedetto
- G Di Perri
- V Fiore
- S Fiorentini
- D Francisci
- C Gandolfo
- C Gervasoni
- V Ghisetti
- R Greco
- G Guarona
- M Iannetta
- L Li Puma
- V. Malagnino
- G Mancuso
- C Mastroianni
- I Menozzi
- E Milano
- A Miola
- M Morganti
- L Monno
- G Noberasco
- G Nunnari
- V Onofri
- A Orsi
- MG Pierfranceschi
- S Pongolini
- D Ripamonti
- S Rubino
- L Ruggerone
- D Russignaga
- C Sagnelli
- M Sanguinetti
- L Sarmati
- L Sasset
- E Scaltriti
- R Schiavo
- M Schioppa
- S Testa
- C Turchi
- O Turriziani
- E Venanzi Rollo
- S Zanussi
- A Zoncada
DOIAbstract
The aim of this study is the characterization and genomic tracing by phylogenetic analyses of 59 new SARS-CoV-2 Italian isolates obtained from patients attending clinical centres in North and Central Italy until the end of April 2020. All but one of the newly-characterized genomes belonged to the lineage B.1, the most frequently identified in European countries, including Italy. Only a single sequence was found to belong to lineage B. A mean of 6 nucleotide substitutions per viral genome was observed, without significant differences between synonymous and non-synonymous mutations, indicating genetic drift as a major source for virus evolution. tMRCA estimation confirmed the probable origin of the epidemic between the end of January and the ...
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