Severe thiamine deficiency complicated by weight loss protects against renal ischaemia-reperfusion injury in rats
- Klooster, A.
- Larkin, J. R.
- Antonysunil, Adaikalakoteswari
- Gans, R. O. B.
- van Goor, H.
- Thornalley, Paul J.
- Rabbani, Naila
- Navis, G.
- Leuvenink, H. G. D.
- Bakker, S. J. L.
DOIAbstract
Injury due to reperfusion after prior ischaemia (IRI) is an important cause of delayed graft function after renal transplantation [1]. Studies in dogs and rats suggest that thiamine is protective against IRI in heart and brain [2–4]. It has been argued that many organs, including kidneys are deficient in thiamine at the moment of transplantation [4]. We aimed to investigate the effect of severe tissue thiamine deficiency on ischaemia-reperfusion injury in rat kidneys
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