Natural selection of human embryos : impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss
- Vitzthum, Virginia J.
- Salker, Madhuri
- Teklenburg, Gijs
- Molokhia, Mariam
- Lavery, Stuart
- Trew, Geoffrey
- Aojanepong, Tepchongchit
- Mardon, Helen J.
- Lokugamage, Amali U.
- Rai, Raj
- Landles, Christian
- Roelen, Bernard A. J.
- Quenby, Siobhan
- Kuijk, Ewart W.
- Kavelaars, Annemieke
- Heijnen, Cobi J.
- Regan, Lesley
- Macklon, Nick S.
- Brosens, Jan J.
Publication date
April 2010
DOI Publisher
Public Library of Science (PLoS) ISSN
1932-6203 Citation count (estimate)
156Abstract
Recurrent pregnancy loss (RPL), defined as 3 or more consecutive miscarriages, is widely attributed either to repeated chromosomal instability in the conceptus or to uterine factors that are poorly defined. We tested the hypothesis that abnormal cyclic differentiation of endometrial stromal cells (ESCs) into specialized decidual cells predisposes to RPL, based on the observation that this process may not only be indispensable for placenta formation in pregnancy but also for embryo recognition and selection at time of implantation
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