Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that play a crucial role in excitatory synaptic transmission in the central nervous system. Each subunit contributes with three helical transmembrane segments (M1, M3, and M4) and a pore loop (M2) to form the channel pore. Recent studies suggest that the architecture of all eukaryotic iGluRs derives from a common prokaryotic ancestral receptor that lacks M4 and consists only of transmembrane segments M1 and M3. Although significant contribution has emerged in the last years, the role of this additionally evolved transmembrane segment in iGluR assembly and function remains unclear. Here, we have investigated how deletions and mutations of M4 in members of the NM...
The ionotropic glutamate receptor family is composed of four unique classes of transmembrane channel...
Glutamate mediates the majority of fast excitatory neurotransmission in the vertebrate brain. Glutam...
NMDA receptors (NMDARs) are excitatory neurotransmitter receptors that form glutamate-gated ion chan...
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that play a crucial...
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that play a crucial...
Ionotropic glutamate receptors (iGluRs), like the NMDA receptor, are ligand-gated ion channels. Thes...
Ionotropic glutamate receptors (iGluRs), including AMPA receptor (AMPAR) and NMDA receptor (NMDAR) s...
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that convey the maj...
N-methyl-d-aspartate (NMDA) receptors composed of glycine-binding GluN1 and GluN3 subunits function ...
N-methyl-d-aspartate (NMDA) receptors composed of glycine-binding GluN1 and GluN3 subunits function ...
N-methyl-D-aspartate (NMDA) receptors are ligand-gated ion channels activated by agonist glutamate a...
NMDA receptors (NMDARs) are glutamate-gated ion channels present at most excitatory mammalian synaps...
NMDA receptors (NMDARs) are glutamate-gated ion channels present at most excitatory mammalian synaps...
The amino acids L-glutamate and glycine are essential agonists of the excitatory NMDA receptor, a su...
NMDA receptors (NMDARs) form glutamate-gated ion channels that play a critical role in CNS physiolog...
The ionotropic glutamate receptor family is composed of four unique classes of transmembrane channel...
Glutamate mediates the majority of fast excitatory neurotransmission in the vertebrate brain. Glutam...
NMDA receptors (NMDARs) are excitatory neurotransmitter receptors that form glutamate-gated ion chan...
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that play a crucial...
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that play a crucial...
Ionotropic glutamate receptors (iGluRs), like the NMDA receptor, are ligand-gated ion channels. Thes...
Ionotropic glutamate receptors (iGluRs), including AMPA receptor (AMPAR) and NMDA receptor (NMDAR) s...
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that convey the maj...
N-methyl-d-aspartate (NMDA) receptors composed of glycine-binding GluN1 and GluN3 subunits function ...
N-methyl-d-aspartate (NMDA) receptors composed of glycine-binding GluN1 and GluN3 subunits function ...
N-methyl-D-aspartate (NMDA) receptors are ligand-gated ion channels activated by agonist glutamate a...
NMDA receptors (NMDARs) are glutamate-gated ion channels present at most excitatory mammalian synaps...
NMDA receptors (NMDARs) are glutamate-gated ion channels present at most excitatory mammalian synaps...
The amino acids L-glutamate and glycine are essential agonists of the excitatory NMDA receptor, a su...
NMDA receptors (NMDARs) form glutamate-gated ion channels that play a critical role in CNS physiolog...
The ionotropic glutamate receptor family is composed of four unique classes of transmembrane channel...
Glutamate mediates the majority of fast excitatory neurotransmission in the vertebrate brain. Glutam...
NMDA receptors (NMDARs) are excitatory neurotransmitter receptors that form glutamate-gated ion chan...