Sequential Domino One-Pot Processes: Synthesis of Heterocyclic Compounds

One-pot synthetic processes are considered as convenient methods to synthesize organic molecules with high degree of complexity, without isolating intermediates. Such one-pot processes could be made possible by using one metal complex to catalyze a multiple reactions sequence or by adding various metal catalysts in a sequential manner to achieve multiple reaction sequence. These processes have proven to have several advantages over step-wise operations, as they avoid the isolation of intermediate species, thereby considerably reducing waste generation, increasing efficiency, minimizing the use of solvents, reagents, time and energy. Moreover, it was also found that in most cases the overall yields in one-pot processes are usually higher than those obtained from the corresponding step-wise operations. Herein, one-pot synthetic strategies have been developed for tetrahydroisoquinolines, cinnamate diesters, isochromenes, 2-benzoxepines and aryl-indenoindoles