INTRODUCTION: Venlafaxine (VEN) is a serotonin-norepinephrine-dopamine reuptake inhibitor that causes usually a mild cardiotoxicity when ingested in overdose. We report a patient who developed acute heart failure following overdose. As the toxicokinetic data suggested a prolonged metabolism, genetic polymorphisms for cytochrome P450 isoenzymes CYP2D6 and CYP2C19 were also investigated. CASE REPORT: A 34-year-old woman was admitted to the hospital 10 hours after the ingestion of an 11.25 g overdose of VEN. She was comatose and suffered two self-limited seizures. The electrocardiogram showed diffuse ST segment depression, but normal QRS and QTc duration. The plasma levels on admission were 18,015 and 3,846 ng/ml for VEN and the metaboli...
pharmacokinetic data on drug disposition. 2 Case report. Serial venlafaxine levels were measured and...
Dear Editor, An 18-year-old woman was admitted six hours after the ingestion of a maximal estimated ...
Although venlafaxine is usually associated with modest increases in blood pressure and not so often ...
Venlafaxine (VEN) is a serotonin-norepinephrine-dopamine reuptake inhibitor that causes usually a mi...
Acute poisoning by large venlafaxine (VEN) overdoses may result in serious cardiac events like acute...
OBJECTIVE: Venlafaxine is a bicyclic antidepressant that may be associated with severe cardiotoxicit...
Cardiotoxicity has been extensively reported in venlafaxine (VEN) overdoses. Asthenia is also among ...
OBJECTIVE : Large overdoses of venlafaxine may induce acute heart failure with severe left ventricul...
Venlafaxine is a serotonin-norepinephrine reuptake inhibitor used as an antidepressant. Interindivid...
Background: Venlafaxine (V) is a serotonin-norepinephrine selective reuptake inhibitor, mainly metab...
Aims: To investigate serial electrocardiogram (ECG) parameters, haemodynamic changes and arrhythmias...
Venlafaxine (VEN) is an antidepressant drug mainly metabolized by the cytochrome P450 (CYP) enzyme C...
Context: Desvenlafaxine is used to treat major depression. Desvenlafaxine is also the active metabol...
A 40-year-old white woman with a history of venlafaxine abuse was admitted to our emergency departme...
Understanding the mechanisms of drug metabolism and interactions can help to prevent side-effects. N...
pharmacokinetic data on drug disposition. 2 Case report. Serial venlafaxine levels were measured and...
Dear Editor, An 18-year-old woman was admitted six hours after the ingestion of a maximal estimated ...
Although venlafaxine is usually associated with modest increases in blood pressure and not so often ...
Venlafaxine (VEN) is a serotonin-norepinephrine-dopamine reuptake inhibitor that causes usually a mi...
Acute poisoning by large venlafaxine (VEN) overdoses may result in serious cardiac events like acute...
OBJECTIVE: Venlafaxine is a bicyclic antidepressant that may be associated with severe cardiotoxicit...
Cardiotoxicity has been extensively reported in venlafaxine (VEN) overdoses. Asthenia is also among ...
OBJECTIVE : Large overdoses of venlafaxine may induce acute heart failure with severe left ventricul...
Venlafaxine is a serotonin-norepinephrine reuptake inhibitor used as an antidepressant. Interindivid...
Background: Venlafaxine (V) is a serotonin-norepinephrine selective reuptake inhibitor, mainly metab...
Aims: To investigate serial electrocardiogram (ECG) parameters, haemodynamic changes and arrhythmias...
Venlafaxine (VEN) is an antidepressant drug mainly metabolized by the cytochrome P450 (CYP) enzyme C...
Context: Desvenlafaxine is used to treat major depression. Desvenlafaxine is also the active metabol...
A 40-year-old white woman with a history of venlafaxine abuse was admitted to our emergency departme...
Understanding the mechanisms of drug metabolism and interactions can help to prevent side-effects. N...
pharmacokinetic data on drug disposition. 2 Case report. Serial venlafaxine levels were measured and...
Dear Editor, An 18-year-old woman was admitted six hours after the ingestion of a maximal estimated ...
Although venlafaxine is usually associated with modest increases in blood pressure and not so often ...