Many bacteria and actinomycetales use L-cysteine biosynthesis to increase their tolerance to antibacterial treatment and establish a long-lasting infection. In turn, this might lead to the onset of antimicrobial resistance that currently represents one of the most menacing threats to public health worldwide. The biosynthetic machinery required to synthesise L-cysteine is absent in mammals; therefore, its exploitation as a drug target is particularly promising. In this article, we report a series of inhibitors of Salmonella thyphimurium serine acetyltransferase (SAT), the enzyme that catalyzes the rate-limiting step of L-cysteine biosynthesis. The development of such inhibitors started with the virtual screening of an in-house library of com...
Antibacterial adjuvants are of great significance, since they allow the therapeutic dose of conventi...
Cysteine is the main precursor of sulfur‐containing biological molecules in bacteria and contributes...
The last step of cysteine biosynthesis in bacteria and plants is catalyzed by O-acetylserine sulfhyd...
Many bacteria and actinomycetales use L-cysteine biosynthesis to increase their tolerance to antibac...
Many bacteria and actinomycetales use L-cysteine biosynthesis to increase their tolerance to antibac...
In Ï'-proteobacteria and Actinomycetales, cysteine biosynthetic enzymes are indispensable during per...
In Upsilon-proteobacteria and Actinomycetales, cysteine biosynthetic enzymes are indispensable durin...
The lack of efficacy of current antibacterials to treat multidrug resistant bacteria poses a life-th...
Cysteine is a building block for several biomolecules that are crucial for living organisms. The las...
Worldwide emergence of resistant bacteria is endangering the efficacy of antibiotics, which have sav...
Emerging antibiotic resistance represents a major hazard for public health. The necessity for develo...
Several bacteria rely on the reductive sulphur assimilation pathway, absent in mammals, to synthesis...
Cysteine is a building block for several biomolecules that are crucial for living organisms. The las...
Several bacteria rely on the reductive sulphur assimilation pathway, absent in mammals, to synthesis...
The inhibition of cysteine biosynthesis in prokaryotes and protozoa has been proposed to be relevant...
Antibacterial adjuvants are of great significance, since they allow the therapeutic dose of conventi...
Cysteine is the main precursor of sulfur‐containing biological molecules in bacteria and contributes...
The last step of cysteine biosynthesis in bacteria and plants is catalyzed by O-acetylserine sulfhyd...
Many bacteria and actinomycetales use L-cysteine biosynthesis to increase their tolerance to antibac...
Many bacteria and actinomycetales use L-cysteine biosynthesis to increase their tolerance to antibac...
In Ï'-proteobacteria and Actinomycetales, cysteine biosynthetic enzymes are indispensable during per...
In Upsilon-proteobacteria and Actinomycetales, cysteine biosynthetic enzymes are indispensable durin...
The lack of efficacy of current antibacterials to treat multidrug resistant bacteria poses a life-th...
Cysteine is a building block for several biomolecules that are crucial for living organisms. The las...
Worldwide emergence of resistant bacteria is endangering the efficacy of antibiotics, which have sav...
Emerging antibiotic resistance represents a major hazard for public health. The necessity for develo...
Several bacteria rely on the reductive sulphur assimilation pathway, absent in mammals, to synthesis...
Cysteine is a building block for several biomolecules that are crucial for living organisms. The las...
Several bacteria rely on the reductive sulphur assimilation pathway, absent in mammals, to synthesis...
The inhibition of cysteine biosynthesis in prokaryotes and protozoa has been proposed to be relevant...
Antibacterial adjuvants are of great significance, since they allow the therapeutic dose of conventi...
Cysteine is the main precursor of sulfur‐containing biological molecules in bacteria and contributes...
The last step of cysteine biosynthesis in bacteria and plants is catalyzed by O-acetylserine sulfhyd...