The signal transduction pathways that mediate the mitogenic response of muscarinic acetylcholine receptors in astroglial cells have not been fully elucidated. In this study we investigated the activation of p70S6 kinase (p70S6K) by carbachol in 1321 N1 astroctyoma cells. Carbachol induced a dose- and time-dependent activation of p70S6K, as evidenced by increased phosphorylation at Thr-389, Thr-421 and Ser-424, by increased p70S6K activity, and by a shift in its molecular weight. Activation of p70S6K was mediated by M3 muscarinic acetylcholine receptors (mAChRs) and was inhibited by two phosphatidylinositol-3-kinase (P13-K) inhibitors, by a pseudosubstrate to protein kinase C (PKC) ζ, and by the p70S6K inhibitor rapamycin. Carbachol-induced ...
Previous studies suggest that the effects of ethanol on carbachol-stimulated I(1,4,5)P3 formation an...
In utero exposure to ethanol is deleterious to fetal brain development. Children born with the fetal...
Thesis (Ph. D.)--University of Washington, 1999A major and irreversible effect seen in the Fetal Alc...
The signal transduction pathways that mediate the mitogenic response of muscarinic acetylcholine rec...
Inhibition of astrocyte proliferation has been suggested to be an important event in the development...
Activation of muscarinic receptors leads to proliferation of astroglial cells and this effect is inh...
Mitogen-activated protein kinase (MAPK) can be phosphorylated by mitogens binding to G-protein-coupl...
Stimulation of Gq-coupled acetylcholine muscarinic receptors leads to proliferation of astroglial ce...
Central nervous system dysfunctions (most notably microencephaly and mental retardation) are among t...
Acetylcholine has been shown to induce proliferation of human astrocytoma cells by activating muscar...
Acetylcholine and other muscarinic agonists stimulate the proliferation of rat cortical astrocytes a...
Acetylcholine has been shown to induce proliferation of human astrocytoma cells by activating muscar...
Ethanol is a potent inhibitor of muscarinic receptor-mediated proliferation in glial cells. Glial pr...
In utero alcohol exposure can lead to fetal alcohol spectrum disorders, characterized by cognitive a...
In 1321N1 astrocytoma cells, carbachol stimulation of M3 muscarinic cholinergic receptors, coupled t...
Previous studies suggest that the effects of ethanol on carbachol-stimulated I(1,4,5)P3 formation an...
In utero exposure to ethanol is deleterious to fetal brain development. Children born with the fetal...
Thesis (Ph. D.)--University of Washington, 1999A major and irreversible effect seen in the Fetal Alc...
The signal transduction pathways that mediate the mitogenic response of muscarinic acetylcholine rec...
Inhibition of astrocyte proliferation has been suggested to be an important event in the development...
Activation of muscarinic receptors leads to proliferation of astroglial cells and this effect is inh...
Mitogen-activated protein kinase (MAPK) can be phosphorylated by mitogens binding to G-protein-coupl...
Stimulation of Gq-coupled acetylcholine muscarinic receptors leads to proliferation of astroglial ce...
Central nervous system dysfunctions (most notably microencephaly and mental retardation) are among t...
Acetylcholine has been shown to induce proliferation of human astrocytoma cells by activating muscar...
Acetylcholine and other muscarinic agonists stimulate the proliferation of rat cortical astrocytes a...
Acetylcholine has been shown to induce proliferation of human astrocytoma cells by activating muscar...
Ethanol is a potent inhibitor of muscarinic receptor-mediated proliferation in glial cells. Glial pr...
In utero alcohol exposure can lead to fetal alcohol spectrum disorders, characterized by cognitive a...
In 1321N1 astrocytoma cells, carbachol stimulation of M3 muscarinic cholinergic receptors, coupled t...
Previous studies suggest that the effects of ethanol on carbachol-stimulated I(1,4,5)P3 formation an...
In utero exposure to ethanol is deleterious to fetal brain development. Children born with the fetal...
Thesis (Ph. D.)--University of Washington, 1999A major and irreversible effect seen in the Fetal Alc...