Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease
- Webb TR
- Erdmann J
- Stirrups KE
- Stitziel NO
- Masca NGD
- Jansen H
- Kanoni S
- Nelson CP
- Ferrario PG
- Konig IR
- Eicher JD
- Johnson AD
- Hamby SE
- Betsholtz C
- Ruusalepp A
- Franzen O
- Schadt EE
- Bjorkegren JLM
- Weeke PE
- Auer PL
- Schick UM
- Lu YC
- Zhang H
- Dube MP
- Goel A
- Farrall M
- Peloso GM
- Won HH
- Do R
- van Iperen E
- Kruppa J
- Mahajan A
- Scott RA
- Willenborg C
- Braund PS
- van Capelleveen JC
- Doney ASF
- Donnelly LA
- Asselta R
- Merlini PA
- Duga S
- Marziliano N
- Denny JC
- Shaffer C
- El-Mokhtari NE
- Franke A
- Heilmann S
- Hengstenberg C
- Hoffmann P
- Holmen OL
- Hveem K
- Jansson JH
- Jockel KH
- Kessler T
- Kriebel J
- Laugwitz KL
- Marouli E
- Martinelli N
- McCarthy MI
- Van Zuydam NR
- Meisinger C
- Esko T
- Mihailov E
- Escher SA
- Alver M
- Moebus S
- Morris AD
- Virtamo J
- Nikpay M
- Olivieri O
- Provost S
- AlQarawi A
- Robertson NR
- Akinsansya KO
- Reilly DF
- Vogt TF
- Yin W
- Asselbergs FW
- Kooperberg C
- Jackson RD
- Stahl E
- Muller-Nurasyid M
- Strauch K
- Varga TV
- Waldenberger M
- Zeng LY
- Chowdhury R
- Salomaa V
- Ford I
- Jukema JW
- Amouyel P
- Kontto J
- Nordestgaard BG
- Ferrieres J
- Saleheen D
- Sattar N
- Surendran P
- Wagner A
- Young R
- Howson JMM
- Butterworth AS
- Danesh J
- Ardissino D
- Bottinger EP
- Erbel R
- Franks PW
- Girelli D
- Hall AS
- Hovingh GK
- Kastrati A
- Lieb W
- Meitinger T
- Kraus WE
- Shah SH
- McPherson R
- Orho-Melander M
- Melander O
- Metspalu A
- Palmer CNA
- Peters A
- Rader DJ
- Reilly MP
- Loos RJF
- Reiner AP
- Roden DM
- Tardif JC
- Thompson JR
- Wareham NJ
- Watkins H
- Willer CJ
- Samani NJ
- Schunkert H
- Deloukas P
- Kathiresan S
DOIAbstract
BACKGROUND Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or traits. OBJECTIVES This study sought to systematically test if genetic variants identified for non-CAD diseases/traits also associate with CAD and to undertake a comprehensive analysis of the extent of pleiotropy of all CAD loci. METHODS In discovery analyses involving 42,335 CAD cases and 78,240 control subjects we tested the association of 29,383 common (minor allele frequency >5%) single nucleotide polymorphisms available on the exome array, which included a substantial proportion of known or suspected single nucleotide poly...
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