Abstract The accurate assessment of infants\u27 pain is important for understanding their medical conditions and developing suitable treatment. Pediatric studies reported that the inadequate treatment of infants\u27 pain might cause various neuroanatomical and psychological problems. The fact that infants can not communicate verbally motivates increasing interests to develop automatic pain assessment system that provides continuous and accurate pain assessment. In this paper, we propose a new set of pain facial activity features to describe the infants\u27 facial expression of pain. Both dynamic facial texture feature and dynamic geometric feature are extracted from video sequences and utilized to classify facial expression of infants as pa...