Cisplatin (CDDP) is one of the most effective chemotherapeutic agents, used for the treatment of diverse tumors, including neuroblastoma and glioblastoma. CDDP induces cell death through different apoptotic pathways. Despite its clinical benefits, CDDP causes several side effects and drug resistance.[Pt(O,O′-acac)(γ-acac)(DMS)], namely PtAcacDMS, a new platinum(II) complex containing two acetylacetonate (acac) and a dimethylsulphide (DMS) in the coordination sphere of metal, has been recently synthesized and showed 100 times higher cytotoxicity than CDDP. Additionally, PtAcacDMS was associated to a decreased neurotoxicity in developing rat central nervous system, also displaying great antitumor and antiangiogenic activity both in vivo and i...
Epigenetic agents such as histone deacetylase (HDAC) inhibitors are widely investigated for use in c...
The demonstration in the 1960s that cis-diammine-dichloroplatinum(II), or cisplatin, inhibits cellul...
[Pt(O,O'-acac)(gamma-acac)(DMS)] (PtAcD) is able to induce apoptosis in various human cancer cells, ...
Cisplatin (CDDP) is one of the most effective chemotherapeutic agents, used for the treatment of div...
Cisplatin (CDDP) is one of the most effective chemotherapeutic agents, used for the treatment of div...
The higher and selective cytotoxicity of [Pt(O,O′-acac)(γ-acac)(DMS)] towards cancer cell in both im...
Platinum compounds cause significant clinical neurotoxicity. Several studies highlight neurological ...
Cisplatin is one of the most active chemotherapeutic agents used in the treatment of childhood and a...
Cisplatin is one of the most active chemotherapeutic agents used in the treatment of childhood and a...
Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect of platinum-based chemotherapy an...
Malignant pleural mesothelioma (MPM) is an aggressive malignancy highly resistant to chemotherapy. T...
Epigenetic agents such as histone deacetylase (HDAC) inhibitors are widely investigated for use in c...
BACKGROUND AND PURPOSE: The aim of this study was to determine whether [platinum (Pt)(O,O'-acetylac...
In the field of experimental oncology, many efforts are being carried out to search new platinum-bas...
In this study, the in vitro stability of cisplatin (CisPt) and cationic platinum(II)-complex (caPt(I...
Epigenetic agents such as histone deacetylase (HDAC) inhibitors are widely investigated for use in c...
The demonstration in the 1960s that cis-diammine-dichloroplatinum(II), or cisplatin, inhibits cellul...
[Pt(O,O'-acac)(gamma-acac)(DMS)] (PtAcD) is able to induce apoptosis in various human cancer cells, ...
Cisplatin (CDDP) is one of the most effective chemotherapeutic agents, used for the treatment of div...
Cisplatin (CDDP) is one of the most effective chemotherapeutic agents, used for the treatment of div...
The higher and selective cytotoxicity of [Pt(O,O′-acac)(γ-acac)(DMS)] towards cancer cell in both im...
Platinum compounds cause significant clinical neurotoxicity. Several studies highlight neurological ...
Cisplatin is one of the most active chemotherapeutic agents used in the treatment of childhood and a...
Cisplatin is one of the most active chemotherapeutic agents used in the treatment of childhood and a...
Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect of platinum-based chemotherapy an...
Malignant pleural mesothelioma (MPM) is an aggressive malignancy highly resistant to chemotherapy. T...
Epigenetic agents such as histone deacetylase (HDAC) inhibitors are widely investigated for use in c...
BACKGROUND AND PURPOSE: The aim of this study was to determine whether [platinum (Pt)(O,O'-acetylac...
In the field of experimental oncology, many efforts are being carried out to search new platinum-bas...
In this study, the in vitro stability of cisplatin (CisPt) and cationic platinum(II)-complex (caPt(I...
Epigenetic agents such as histone deacetylase (HDAC) inhibitors are widely investigated for use in c...
The demonstration in the 1960s that cis-diammine-dichloroplatinum(II), or cisplatin, inhibits cellul...
[Pt(O,O'-acac)(gamma-acac)(DMS)] (PtAcD) is able to induce apoptosis in various human cancer cells, ...