Risk of severe non AIDS events is increased among patients unable to increase their CD4 + T-cell counts >200+/μl despite effective HAART
- Lapadula G.
- Chatenoud L.
- Gori A.
- Castelli F.
- Di Giambenedetto S.
- Fabbiani M.
- Maggiolo F.
- Foca E.
- Ladisa N.
- Sighinolfi L.
- Di Pietro M.
- Pan A.
- Torti C.
- Carosi G.
- Quiros E.
- Nasta P.
- Paraninfo G.
- Cauda R.
- Colafigli M.
- Scalzini A.
- Castelnuovo F.
- El Hamad I.
- Mazzotta F.
- Locaputo S.
- Pierotti P.
- Marino N.
- Ble C.
- Vichi F.
- Angarano G.
- Ladisa N.
- Monno L.
- Maggi P.
- Costarelli S.
- Puoti M.
- Viale P.
- Colangeli V.
- Borderi M.
DOIAbstract
Background: Immunological non-response (INR) despite virological suppression is associated with AIDS-defining events/death (ADE). Little is known about its association with serious non-AIDS-defining events (nADE). Methods Patients highly-active antiretroviral therapy (HAART) with <200 CD4+/μl and achieving HIVRNA <50 copies/ml within 12 (±3) months were categorized as INR if CD4+ T-cell count at year 1 was <200/μl. Predictors of nADE (malignancies, severe infections, renal failure-ie, estimated glomerular filtration rate <30 ml/min, cardiovascular events and liver decompensation) were assessed using multivariable Cox models. Follow-up was right-censored in case of HAART discontinuation or confirmed HIV-RNA>50. Results: 1221 p...
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