Tumor Profiling at the Service of Cancer Therapy

Cancer treatment; Personalized medicine; Precision oncologyTratamiento del cáncer; Medicina personalizada; Oncología de precisiónTractament del càncer; Medicina personalitzada; Oncologia de precisióCancer treatment options have evolved significantly in the past few years. From the initial surgical procedures, to the latest next-generation technologies, we are now in the position to analyze and understand tumors in a one-by-one basis and use that to our advantage to provide with individualized treatment options that may increase patient survival. In this review, we will focus on how tumor profiling has evolved over the past decades to deliver more efficient and personalized treatment options, and how novel technologies can help us envisage the future of precision oncology toward a better management and, ultimately, increased survival.This work was funded by AECC grant GC16173720CARR to ÁC, ML, and AC. Also, other sources of funding include the Fundación Ramón Areces; the Spanish Ministry of Science, Innovation and Universities (MCIU- I+D+i 2018), Spanish Research State Agency (AEI), the European Fund for Regional Development (MCIU/AEI/FEDER-UE): grants RTI2018-097455-B-I00 and RED2018-102723-T; CIBER-Onc (grant number CB16/12/00275) and the Economy, Business and Universities Council of the Junta de Andalucia (grant number P18-RT-2501)—to AC; and the Instituto de Salud Carlos III (ISCIII) co-financed by the European Regional Fund (ERDF): grant numbers PI16/01057—to AC and PI15/01262 and CP03/00101—to ML