Ultrasound breast cancer screening in dense parenchyma: The value of computer aided detection system for mammography (single-center, prospective, randomized clinical trial)

Purpose. To compare the results of screening ultrasound (US) in women with dense (ACR C-D) breast parenchyma, with no suspicious changes at mammography, with and without considering the CAD results during the examination. Materials and methods. We randomized 2078 women aged 40-72 years old for breast US (US group) or CAD + breast US with targeted analysis of the areas marked by CAD on the mammograms (CAD + US group). Results. In the US group we found 16 breast carcinomas (BC) (median: 15 mm, range: 8-24 mm), in the CAD + US group - 22 BCs (median: 10 mm, range: 5-24 mm). 3 of the 16 BCs (18.75%) in the US group and 11 of 22 (50.00%) BCs in the CAD + US group (p0.05). During the 3-year follow up we found 9 more BCs in the US group and 2 more BCs in the CAD + US group (p