Alterações oftalmológicas em pacientes pediátricos com leucemia linfoblástica aguda

Introduction: Acute Lymphoblastic Leukemia (ALL) is a cancer commonly found among young people and responsible for 26% of childhood cancer cases. Today, up to 90% of such patients have an average survival rate of five-year free of the illness. Ocular manifestations (OM) arising from ALLs might be secondary to tumor-induced vascular anomalies or related to direct infiltration of the neoplastic cells into the eye and orbit, or to medications used in treatment such as chemotherapy and glucocorticoids (GC). Since this is an oncological disease with a high potential for cure, in young individuals with a high life expectancy, the identification of possible long-term ocular complications resulting from the treatment and correlation with predictive factors of relapse of the disease may support the design of an ophthalmological protocol for these patients cases. yet existent in scientific literature. Objective: To characterize OM in pediatric patients under treatment for ALL and to evaluate if they are associated with predictive risk factors for relapse, with protocols (1999 or 2009), gender and cerebrospinal fluid (CSF) infiltration Methods: A prospective cohort study was conducted in children and adolescents with ALL from January 2013 to December 2017, followed by a systematic review associating pediatric patients under treatment for ALL and ocular hypertension (OH), because OH is the most prevalent OM. The patients underwent ophthalmologic evaluations before starting treatment (D0), on the eighth day (D8), at the 28th day (D28), and at six months (D6 months). Ocular hypertension (OH) was considered in results above 21 mmHg. Measures of visual acuity (VA) 21 mmHg. Medidas de acuidade visual (AV)