Laryngeal and vocal evaluation in isolated growth hormone deficiency (IGHD) individuals.

The voice on congenital isolated growth hormone deficiency (IGHD) is commonly refered high pitched voice . However, vocal and laryngeal data are rare within literature. In Itabaianinha County, Northeast Brazil, it had been described the most extend kindred with severe IGHD due to a GH-realising hormone receptor (GHRHR) gene mutation. The aim of this descriptive transversal study was to evaluate vocal and laryngeal affections in this group. 23 subjects with IGHD were studied, being 6 males and 17 females They were submitted to an otorhinolaryngological evaluation and strobovideolaryngoscopic exam. Besides, a speech evaluation like hearing perception analysis (GRBAS scale) and objective voice evaluation (maximum phonatory time, s/z ratio and acoustic analysis) were also used. The results were performed using qui-square, exact Fisher and unpaired t test (p<0,05). The main vocal complaints were vocal fatigue (36,36%), hoarsenesses (31,81%), sore throat (27,27%), neckache (27,27%), phonatory pain (22,72%) and aphonia (18,18%). No male presented any complaint. Based on findings, vocal abuse (72,72%), etilism (45,45%) and smoking (36,36%) were considered like nocive habits to normal voice. 72,7% of the subjects presented abnormal voice and 27,3% were the normal ones. Amongst the abnormal voice, the mild/moderate grade was prevalent, with the presence of roughness, breathiness and strain. The strobovideoalaryngoscopic exam in 21 subjects showed laryngopharyngeal reflux signs (66,66%), functional dysphonia (52,38%), vocal nodules (23,80%) and vocal cysts (9,52%). There was significant association between vocal complaints and grade of abnormal voice. There weren t association between abnormal voice and laryngeal diseases; nocive habits and abnormal voice; nocive habits and laryngeal diseases; laryngopharyngeal reflux signs and functional dysphonia; vocal complaint and laryngeal diseases. The maximum phonatory time was lower than 10s and s/z ratio was 1,19. In acoustic analysis, fundamental frequency was 221,06 Hz in females and 204,67 Hz in males. There wasn t statistical dependency between genders showing high pitch and dominance IGHD effect above gender. There wasn t statistical dependency between normal and abnormal voice in acoustic analysis neither. Conclusions: Voice presents high pitch in both genders and the most commonly abnormalities were roughness, breathiness and strain. The mild/moderate grade was prevalent. Laryngopharyngeal reflux signs and functional dysphonia were the most reached diagnostics using strobovideolaryngoscopic exam.Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorA voz na deficiência isolada do hormônio de crescimento (DIGH) de início na infância é comumente referida como voz de caráter agudo, porém dados laríngeos e vocais são escassos na literatura. Na cidade de Itabaianinha-SE, no nordeste brasileiro, foi descrito o maior agrupamento familiar com DIGH severa, devido a uma mutação no gene do receptor do hormônio liberador do hormônio do crescimento (GHRHR). O objetivo do presente estudo foi avaliar alterações laríngeas e vocais nessa população, realizando-se um estudo transversal descritivo. Foram, então, estudados 23 indivíduos com DIGH, sendo 6 do sexo masculino e 17 do sexo feminino. Eles foram submetidos à avaliação otorrinolaringológica geral por entrevista e exame videolaringoestroboscópico. Avaliou-se também o grau de alteração na qualidade vocal, através da análise perceptivo-auditiva (escala GRBAS) e avaliação objetiva da voz (tempo máximo de fonação, relação s/z e análise acústica). Para comparação entre os achados, utilizou-se teste do quiquadrado e exato de Fisher (p<0,05) e entre os sexos, na análise acústica, teste t para amostras independentes (p