Add to ORKGSTUDY OBJECTIVES: Fast frequency sleep spindles are reduced in aging and Alzheimer's disease (AD), but the mechanisms and functional relevance of these deficits remains unclear. The study objective was to identify AD biomarkers associated with fast sleep spindle deficits in cognitively unimpaired older adults at risk for AD. METHODS: Fifty-eight cognitively unimpaired, β-amyloid negative, older adults (mean±SD; 61.4±6.3 years, 38 female) enriched with parental history of AD (77.6%) and apolipoprotein E (APOE) ε4 positivity (25.9%) completed the study. Cerebrospinal fluid (CSF) biomarkers of central nervous system (CNS) inflammation, β-amyloid and tau proteins, and neurodegeneration were combined with polysomnography (PSG) using high density...
IMPORTANCE: Increasing evidence suggests a relationship between poor sleep and the risk of developin...
See Mander et al. (doi:10.1093/awx174) for a scientific commentary on this article.Sleep deprivation...
Study Objectives: To investigate the cumulative effect of five consecutive nights of partial sleep ...
STUDY OBJECTIVES: Fast frequency sleep spindles are reduced in aging and Alzheimer's disease (AD), b...
ObjectiveTo determine the relationship between sleep quality and CSF markers of Alzheimer disease (A...
BACKGROUND: Based on associations between sleep spindles, cognition, and sleep-dependent memory pro...
Abstract Background Based on associations between sleep spindles, cognition, and sleep-dependent mem...
Background: Based on associations between sleep spindles, cognition, and sleep-dependent memory proc...
As we age, sleep patterns undergo significant modifications in micro and macrostructure, worsening c...
International audienceObjective: Rapid eye movement (REM) sleep is markedly altered in Alzheimer's d...
Abstract Background: Alzheimer's disease (AD) is frequently accompanied by sleep impairment, whic...
Introduction: Sleep deficits have been linked to dementia including Alzheimer's disease (AD). TheAPO...
Importance: Disrupted sleep commonly occurs with progressing neurodegenerative disease. Large, well-...
BACKGROUND: Alzheimer's disease (AD) is frequently accompanied by sleep impairment, which can induc...
Alteration of sleep quality is a hallmark of the ageing process. The fine-tuned coalescence of eleme...
IMPORTANCE: Increasing evidence suggests a relationship between poor sleep and the risk of developin...
See Mander et al. (doi:10.1093/awx174) for a scientific commentary on this article.Sleep deprivation...
Study Objectives: To investigate the cumulative effect of five consecutive nights of partial sleep ...
STUDY OBJECTIVES: Fast frequency sleep spindles are reduced in aging and Alzheimer's disease (AD), b...
ObjectiveTo determine the relationship between sleep quality and CSF markers of Alzheimer disease (A...
BACKGROUND: Based on associations between sleep spindles, cognition, and sleep-dependent memory pro...
Abstract Background Based on associations between sleep spindles, cognition, and sleep-dependent mem...
Background: Based on associations between sleep spindles, cognition, and sleep-dependent memory proc...
As we age, sleep patterns undergo significant modifications in micro and macrostructure, worsening c...
International audienceObjective: Rapid eye movement (REM) sleep is markedly altered in Alzheimer's d...
Abstract Background: Alzheimer's disease (AD) is frequently accompanied by sleep impairment, whic...
Introduction: Sleep deficits have been linked to dementia including Alzheimer's disease (AD). TheAPO...
Importance: Disrupted sleep commonly occurs with progressing neurodegenerative disease. Large, well-...
BACKGROUND: Alzheimer's disease (AD) is frequently accompanied by sleep impairment, which can induc...
Alteration of sleep quality is a hallmark of the ageing process. The fine-tuned coalescence of eleme...
IMPORTANCE: Increasing evidence suggests a relationship between poor sleep and the risk of developin...
See Mander et al. (doi:10.1093/awx174) for a scientific commentary on this article.Sleep deprivation...
Study Objectives: To investigate the cumulative effect of five consecutive nights of partial sleep ...