The cell is a crowded environment in which interactions between macromolecules, even weak interactions, determine their solubility and the assembly of the labile complexes that operate biological functions. The weak interactions between proteins in solution that define their non-ideal behaviour also control their crystallisation.To which extent do protein – solvent interactions influence protein – protein interactions ? In the present thesis, these two kinds of interaction have been put in relation for the malate dehydrogenase (Hm MalDH) from Haloarcula marismortui. This halophilic protein is very acidic and is solvated by large amounts of water and salt.We have developed a new method for the determination of the second virial coefficient A...
There is a strong link between solubility, and thus crystallisation, and the molecular interactions ...
The interactions in a liquid-liquid (LLPS) phase separated solution induced by adding multivalent io...
ABSTRACT: Protein−protein interactions were investigated for α-chymotrypsinogen by static and dynami...
The cell is a crowded environment in which interactions between macromolecules, even weak interactio...
International audienceIn previous work, malate dehydrogenase from Haloarcula marismortui (hMDH), a h...
Protein-solvent interactions govern the behaviour of proteins isolated from extreme halophiles. In t...
International audienceMalate dehydrogenase from Haloarcula marismortui (hMDH) is active, soluble and...
AbstractWe have investigated the potential of sedimentation velocity analytical ultracentrifugation ...
International audienceProtein-solvent interactions govern the behaviors of proteins isolated from ex...
AbstractProtein self-association may be detrimental in biological systems, but can be utilized in a ...
Protein self-association may be detrimental in biological systems, but can be utilized in a controll...
There is a strong link between solubility, and thus crystallisation, and the molecular interactions ...
Many bioprocess separations involve manipulating the solution conditions to selectively remove or co...
Doctor of PhilosophyDepartment of PhysicsJeremy D. SchmitDiseases such as Alzheimer’s, Parkinson’s, ...
Roberts, Christopher J.The diverse behavior of protein solutions can be attributed to the collection...
There is a strong link between solubility, and thus crystallisation, and the molecular interactions ...
The interactions in a liquid-liquid (LLPS) phase separated solution induced by adding multivalent io...
ABSTRACT: Protein−protein interactions were investigated for α-chymotrypsinogen by static and dynami...
The cell is a crowded environment in which interactions between macromolecules, even weak interactio...
International audienceIn previous work, malate dehydrogenase from Haloarcula marismortui (hMDH), a h...
Protein-solvent interactions govern the behaviour of proteins isolated from extreme halophiles. In t...
International audienceMalate dehydrogenase from Haloarcula marismortui (hMDH) is active, soluble and...
AbstractWe have investigated the potential of sedimentation velocity analytical ultracentrifugation ...
International audienceProtein-solvent interactions govern the behaviors of proteins isolated from ex...
AbstractProtein self-association may be detrimental in biological systems, but can be utilized in a ...
Protein self-association may be detrimental in biological systems, but can be utilized in a controll...
There is a strong link between solubility, and thus crystallisation, and the molecular interactions ...
Many bioprocess separations involve manipulating the solution conditions to selectively remove or co...
Doctor of PhilosophyDepartment of PhysicsJeremy D. SchmitDiseases such as Alzheimer’s, Parkinson’s, ...
Roberts, Christopher J.The diverse behavior of protein solutions can be attributed to the collection...
There is a strong link between solubility, and thus crystallisation, and the molecular interactions ...
The interactions in a liquid-liquid (LLPS) phase separated solution induced by adding multivalent io...
ABSTRACT: Protein−protein interactions were investigated for α-chymotrypsinogen by static and dynami...