Add to ORKGHigh voltage electrical shock can produce extensive muscle and nerve tissue damage due to poration of cell membranes by electric field gradients in addition to thermal denaturation of biomolecules. We studied the therapeutic membrane sealing effect of the surfactant Poloxamer 188 on muscle tissue damage in vivo following non-thermal electrical injury in our rat hind limb model (DC-pulses, 150 V/cm) by radiotracer imaging. Poloxamer 188 surfactant injections (50 mg/kg) showed a significant decrease in radiotracer retention compared to control injections post-shock. The results indicate the importance of membrane permeabilization and the therapeutic potential of surfactant sealing in electrical shock victims
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering, 1989.Biblio...
The effect of a nontoxic, nonionic block co-polymeric surface active agent, poloxamer 188, on electr...
Traumatic injury to the knee leads to the development of post-traumatic osteoarthritis. The objectiv...
High voltage electrical shock can produce extensive muscle and nerve tissue damage due to poration o...
Several years ago, we proposed that loss of cell membrane structural integrity by electroporation Is...
AbstractA critical requirement for cell survival after trauma is sealing of breaks in the cell membr...
In victims of electrical trauma, electroporation of cell membrane, in which lipid bilayer is permeab...
High-voltage electrical shock can produce minimal external signs of damage with widespread damage to...
Objective: This study investigates whether 99mTc pyrophosphate (PYP) imaging provides a quantitative...
An improved voltage clamp with a double vaseline gap chamber was designed to study electroporated sk...
Joule heating has long been considered the principal component of tissue damage in electrical injury...
The effects of large magnitude transmembrane potential pulses on voltage-gated Na and K channel beha...
Neuronal injury resulting from mechanical deformation is poorly characterized at the cellular level....
Key words: severe nerve compression, functional recovery, sonicated lipid emulsion Abstract. Accordi...
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1994.Includes...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering, 1989.Biblio...
The effect of a nontoxic, nonionic block co-polymeric surface active agent, poloxamer 188, on electr...
Traumatic injury to the knee leads to the development of post-traumatic osteoarthritis. The objectiv...
High voltage electrical shock can produce extensive muscle and nerve tissue damage due to poration o...
Several years ago, we proposed that loss of cell membrane structural integrity by electroporation Is...
AbstractA critical requirement for cell survival after trauma is sealing of breaks in the cell membr...
In victims of electrical trauma, electroporation of cell membrane, in which lipid bilayer is permeab...
High-voltage electrical shock can produce minimal external signs of damage with widespread damage to...
Objective: This study investigates whether 99mTc pyrophosphate (PYP) imaging provides a quantitative...
An improved voltage clamp with a double vaseline gap chamber was designed to study electroporated sk...
Joule heating has long been considered the principal component of tissue damage in electrical injury...
The effects of large magnitude transmembrane potential pulses on voltage-gated Na and K channel beha...
Neuronal injury resulting from mechanical deformation is poorly characterized at the cellular level....
Key words: severe nerve compression, functional recovery, sonicated lipid emulsion Abstract. Accordi...
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1994.Includes...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering, 1989.Biblio...
The effect of a nontoxic, nonionic block co-polymeric surface active agent, poloxamer 188, on electr...
Traumatic injury to the knee leads to the development of post-traumatic osteoarthritis. The objectiv...