BACKGROUND AND PURPOSE: Osteopontin (OPN) is neuroprotective in ischemic brain injuries in adult experimental models; therefore, we hypothesized that OPN would provide neuroprotection and improve long-term neurological function in the immature brain after hypoxic-ischemic (HI) injury. METHODS: HI was induced by unilateral ligation of the right carotid artery followed by hypoxia (8% O(2) for 2 hours) in postnatal Day 7 rats. OPN (0.03 μg or 0.1 μg) was injected intracerebroventricularly at 1 hour post-HI. Temporal expression of endogenous OPN was evaluated in the normal rat brain at the age of 0, 4, 7, 11, 14, and 21 days and in the ipsilateral hemisphere after HI. The effects of OPN were evaluated using 2-3-5-triphenyl tetrazolium chloride ...
Objective: To test a possible neuroprotective activity of 17b-estradiol in the neonatal rat brain ex...
Neonatal hypoxic-ischemic encephalopathy (HIE) is an injury that often leads to detrimental neurolog...
WOS: 000291330700015Objective: Cyclooxygenase pathway and prostaglandins play an important role in t...
BACKGROUND AND PURPOSE: Osteopontin (OPN) is neuroprotective in ischemic brain injuries in adult exp...
Background and Purpose—Osteopontin (OPN) is neuroprotective in ischemic brain injuries in adult expe...
Neonatal encephalopathy due to perinatal hypoxia-ischemia (HI) is a severe condition, and current tr...
Background and Purpose—Hypoxic–ischemic (HI) brain injury is a frequent cause of perinatal morbidity...
BACKGROUND: Osteopontin (OPN), an extracellular matrix glycoprotein, has been reported to inhibit in...
Aims: To investigate the mechanisms of neuronal cell death after hypoxia-ischemia in the developing ...
The glycoprotein osteopontin is highly upregulated in central nervous system (CNS) disorders such as...
The pathophysiological mechanisms underlying the development of hypoxic-ischemic (HI) brain injury h...
Perinatal brain injury, as a result of hypoxia-ischemia (HI) or infection/HI, is a major cause of ac...
Purpose: To investigate the neuroprotective efficacy of plant polyphenol luteolin against hypoxic is...
Perinatal hypoxia-ischemia remains the single most important cause of brain injury in the newborn, l...
Hypoxia-ischemia is a major cause of perinatal brain injury in the newborn. Neotrofin, a neurotrophi...
Objective: To test a possible neuroprotective activity of 17b-estradiol in the neonatal rat brain ex...
Neonatal hypoxic-ischemic encephalopathy (HIE) is an injury that often leads to detrimental neurolog...
WOS: 000291330700015Objective: Cyclooxygenase pathway and prostaglandins play an important role in t...
BACKGROUND AND PURPOSE: Osteopontin (OPN) is neuroprotective in ischemic brain injuries in adult exp...
Background and Purpose—Osteopontin (OPN) is neuroprotective in ischemic brain injuries in adult expe...
Neonatal encephalopathy due to perinatal hypoxia-ischemia (HI) is a severe condition, and current tr...
Background and Purpose—Hypoxic–ischemic (HI) brain injury is a frequent cause of perinatal morbidity...
BACKGROUND: Osteopontin (OPN), an extracellular matrix glycoprotein, has been reported to inhibit in...
Aims: To investigate the mechanisms of neuronal cell death after hypoxia-ischemia in the developing ...
The glycoprotein osteopontin is highly upregulated in central nervous system (CNS) disorders such as...
The pathophysiological mechanisms underlying the development of hypoxic-ischemic (HI) brain injury h...
Perinatal brain injury, as a result of hypoxia-ischemia (HI) or infection/HI, is a major cause of ac...
Purpose: To investigate the neuroprotective efficacy of plant polyphenol luteolin against hypoxic is...
Perinatal hypoxia-ischemia remains the single most important cause of brain injury in the newborn, l...
Hypoxia-ischemia is a major cause of perinatal brain injury in the newborn. Neotrofin, a neurotrophi...
Objective: To test a possible neuroprotective activity of 17b-estradiol in the neonatal rat brain ex...
Neonatal hypoxic-ischemic encephalopathy (HIE) is an injury that often leads to detrimental neurolog...
WOS: 000291330700015Objective: Cyclooxygenase pathway and prostaglandins play an important role in t...