The Development of a New Water-Soluble Zinc Porphyrin, ZnTTP-3AP, and Its Potential as Photodynamic Therapy Agent

Photodynamic Therapy (PDT) is a treatment being developed for various medical disorders. PDT uses the radiant energy of light and a photosensitive agent for treatment. A novel water-soluble zinc(II) porphyrin was developed as a potential PDT agent. When activated by light, a singlet oxygen is generated which affects the surrounding cells. The goal of this research was to synthesize and characterize a new water-soluble zinc(II) porphyrin incorporating 3-amino-1-propanol. An MTT assay utilizing A549 lung cancer cells was completed to evaluate the cytotoxicity of ZnTPP-3AP. Preliminary results indicate ZnTPP-3AP has promise as a potential PDT agent