Six structurally related 3-keto-substituted macrolide antibiotics (ketolides) were compared for concentration-dependent inhibitory effects on growth rate, viable cell number, and protein synthesis rates in Staphylococcus aureus cells. Inhibitory effects on 50S ribosomal subunit formation were also examined, as this is a second target for these antibiotics. A concentration range of 0.01 to 0.1 μg/ml was tested. An IC50 for inhibition of translation and 50S synthesis was measured for each compound, to relate structural features to inhibitory activity. ABT-773 was the most effective of the six compounds tested with an IC50 = 0.035 μg/ml. HMR 3004 was almost as effective with an IC50 = 0.05 μg/ml. Two 2-fluoroketolides (HMR 3562 and HMR 3787) w...
The new ketolide antibiotic telithromycin (HMR3647) has been examined for inhibitory effects in cell...
The continuing increase in antibiotic-resistant pathogenic bacterial has stimulated research on the ...
Methicillin-resistant Staphylococcus aureus cells were treated with three macrolide antibiotics to e...
Six structurally related 3-keto-substituted macrolide antibiotics (ketolides) were compared for conc...
Eleven structurally similar ketolide antibiotics were tested at a concentration of 1 μg/ml for their...
ABT-773 is a new 3-keto macrolide antibiotic that has been shown to be very effective against infect...
The ketolide antibiotics are semi-synthetic derivatives of erythromycin A with enhanced inhibitory a...
Since their discovery, the macrolide antimicrobials have proved clinically valuable for the treatmen...
The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribos...
Ketolides are the most recent generation of antimicrobials derived from the 14-membered ring macroli...
Nine structurally similar macrolide antibiotics were tested at a concentration of 0.5 μg/ml for thei...
We characterized the mechanism of action and the drug-binding site of a novel ketolide, CEM-101, whi...
Three pairs of related macrolide antibiotics, differing at the 11,12 position of the macrolactone ri...
We characterized the mechanism of action and the drug-binding site of a novel ketolide, CEM-101, whi...
A prior study examining differences in the activities of erythromycin and azithromycin on cellular f...
The new ketolide antibiotic telithromycin (HMR3647) has been examined for inhibitory effects in cell...
The continuing increase in antibiotic-resistant pathogenic bacterial has stimulated research on the ...
Methicillin-resistant Staphylococcus aureus cells were treated with three macrolide antibiotics to e...
Six structurally related 3-keto-substituted macrolide antibiotics (ketolides) were compared for conc...
Eleven structurally similar ketolide antibiotics were tested at a concentration of 1 μg/ml for their...
ABT-773 is a new 3-keto macrolide antibiotic that has been shown to be very effective against infect...
The ketolide antibiotics are semi-synthetic derivatives of erythromycin A with enhanced inhibitory a...
Since their discovery, the macrolide antimicrobials have proved clinically valuable for the treatmen...
The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribos...
Ketolides are the most recent generation of antimicrobials derived from the 14-membered ring macroli...
Nine structurally similar macrolide antibiotics were tested at a concentration of 0.5 μg/ml for thei...
We characterized the mechanism of action and the drug-binding site of a novel ketolide, CEM-101, whi...
Three pairs of related macrolide antibiotics, differing at the 11,12 position of the macrolactone ri...
We characterized the mechanism of action and the drug-binding site of a novel ketolide, CEM-101, whi...
A prior study examining differences in the activities of erythromycin and azithromycin on cellular f...
The new ketolide antibiotic telithromycin (HMR3647) has been examined for inhibitory effects in cell...
The continuing increase in antibiotic-resistant pathogenic bacterial has stimulated research on the ...
Methicillin-resistant Staphylococcus aureus cells were treated with three macrolide antibiotics to e...