Objective: Midlife obesity is a risk factor for dementia development. Obesity has also been linked to hyperaldosteronism, and this can be modeled in rats by high fat (HF) feeding from weaning. Aldosterone, or activation of the mineralocorticoid receptor (MR) causes cerebrovascular injury in lean hypertensive rats. We hypothesized that rats fed a HF diet would show inward middle cerebral artery (MCA) remodeling that could be prevented by MR antagonism. We further proposed that the cerebral artery remodeling would be associated with white mater injury. Methods: Three-week-old male Sprague-Dawley rats were fed a HF diet ± the MR antagonist canrenoic acid (Canr) for 17 weeks. Control rats received normal chow (control NC). MCA structure was ass...
The metabolic syndrome (MetS) is highly prevalent in the North American population and is associated...
We have previously demonstrated that diet-induced obese (DIO) rats fed a high-fat, high-dextrose (HF...
OBJECTIVE: The hypothalamus of hypercaloric diet-induced obese animals is featured by a significant ...
Obesity represents an independent risk factor for the development of cerebrovascular disease and cog...
INTRODUCTION. Obesity, is considered a medical challenge for its increase worldwide. It represents ...
Obesity is an excessive or abnormal accumulation of adipose tissue due to a high-caloric diet and/or...
International audienceBackground and purpose: Mineralocorticoid receptor (MR) activation contributes...
The systemic effects, such as increased fat mass, hypertension, insulin resistance and metabolic dis...
Neuroinflammation and cognitive impairment are associated with obesity-related disorders. High-fat d...
Increased food intake, reduced physical activity and altered metabolic processes are the variables t...
Scope: Cholesterol homeostasis is crucial for brain functioning. Unhealthy nutrition can influence c...
The metabolic syndrome (MetS) is highly prevalent in the North American population and is associated...
We have previously demonstrated that diet-induced obese (DIO) rats fed a high-fat, high-dextrose (HF...
OBJECTIVE: The hypothalamus of hypercaloric diet-induced obese animals is featured by a significant ...
Obesity represents an independent risk factor for the development of cerebrovascular disease and cog...
INTRODUCTION. Obesity, is considered a medical challenge for its increase worldwide. It represents ...
Obesity is an excessive or abnormal accumulation of adipose tissue due to a high-caloric diet and/or...
International audienceBackground and purpose: Mineralocorticoid receptor (MR) activation contributes...
The systemic effects, such as increased fat mass, hypertension, insulin resistance and metabolic dis...
Neuroinflammation and cognitive impairment are associated with obesity-related disorders. High-fat d...
Increased food intake, reduced physical activity and altered metabolic processes are the variables t...
Scope: Cholesterol homeostasis is crucial for brain functioning. Unhealthy nutrition can influence c...
The metabolic syndrome (MetS) is highly prevalent in the North American population and is associated...
We have previously demonstrated that diet-induced obese (DIO) rats fed a high-fat, high-dextrose (HF...
OBJECTIVE: The hypothalamus of hypercaloric diet-induced obese animals is featured by a significant ...