Background Polyadenylation plays a key role in producing mature mRNAs in eukaryotes. It is widely believed that the poly(A)-binding proteins (PABs) uniformly bind to poly(A)-tailed mRNAs, regulating their stability and translational efficiency. Results We observe that the homozygous triple mutant of broadly expressed Arabidopsis thaliana PABs, AtPAB2, AtPAB4, and AtPAB8, is embryonic lethal. To understand the molecular basis, we characterize the RNA-binding landscape of these PABs. The AtPAB-binding efficiency varies over one order of magnitude among genes. To identify the sequences accounting for the variation, we perform poly(A)-seq that directly sequences the full-length poly(A) tails. More than 10% of poly(A) tails contain at least one ...
All eukaryotic mRNAs of nuclear origin are modified with a 5' cap and a 3' poly(A) tail. These stru...
BACKGROUND: The polyadenylation of mRNA is one of the critical processing steps during expression of...
Messenger RNA (mRNA) polyadenylation is an indispensable step during post-transcriptional pre-mRNA p...
<div><p>The poly(A) tail at 3’ ends of eukaryotic mRNAs promotes their nuclear export, stability and...
The poly(A) tail at 3’ ends of eukaryotic mRNAs promotes their nuclear export, stability and transla...
The poly(A) tail at 3’ ends of eukaryotic mRNAs promotes their nuclear export, stability and transla...
The poly(A) tail at 3' ends of eukaryotic mRNAs promotes their nuclear export, stability and transla...
Nearly all eukaryotic RNAs have a continual tract of polyadenosine at their end, called a poly(A) ta...
AbstractPoly(A) binding protein (PABP) is an essential, well-conserved, multifunctional protein invo...
Poly(A)-binding proteins (PABs) bind to the poly(A) tails of most eukaryotic mRNAs and thereby influ...
Summary: In eukaryotes, mRNA 3′-polyadenylation triggers poly(A) binding protein (PABP) recruitment ...
Polyadenylation of pre-mRNAs is critical for efficient nuclear export, stability, and translation of...
In animal oocytes and early embryos, mRNA poly(A)-tail length strongly influences translational effi...
Most eukaryotic mRNAs are subject to considerable post-transcriptional modification, including cappi...
In eukaryotic cells, newly synthesized mRNAs acquire a poly(A) tail that plays several fundamental r...
All eukaryotic mRNAs of nuclear origin are modified with a 5' cap and a 3' poly(A) tail. These stru...
BACKGROUND: The polyadenylation of mRNA is one of the critical processing steps during expression of...
Messenger RNA (mRNA) polyadenylation is an indispensable step during post-transcriptional pre-mRNA p...
<div><p>The poly(A) tail at 3’ ends of eukaryotic mRNAs promotes their nuclear export, stability and...
The poly(A) tail at 3’ ends of eukaryotic mRNAs promotes their nuclear export, stability and transla...
The poly(A) tail at 3’ ends of eukaryotic mRNAs promotes their nuclear export, stability and transla...
The poly(A) tail at 3' ends of eukaryotic mRNAs promotes their nuclear export, stability and transla...
Nearly all eukaryotic RNAs have a continual tract of polyadenosine at their end, called a poly(A) ta...
AbstractPoly(A) binding protein (PABP) is an essential, well-conserved, multifunctional protein invo...
Poly(A)-binding proteins (PABs) bind to the poly(A) tails of most eukaryotic mRNAs and thereby influ...
Summary: In eukaryotes, mRNA 3′-polyadenylation triggers poly(A) binding protein (PABP) recruitment ...
Polyadenylation of pre-mRNAs is critical for efficient nuclear export, stability, and translation of...
In animal oocytes and early embryos, mRNA poly(A)-tail length strongly influences translational effi...
Most eukaryotic mRNAs are subject to considerable post-transcriptional modification, including cappi...
In eukaryotic cells, newly synthesized mRNAs acquire a poly(A) tail that plays several fundamental r...
All eukaryotic mRNAs of nuclear origin are modified with a 5' cap and a 3' poly(A) tail. These stru...
BACKGROUND: The polyadenylation of mRNA is one of the critical processing steps during expression of...
Messenger RNA (mRNA) polyadenylation is an indispensable step during post-transcriptional pre-mRNA p...