The Cenozoic evolution of the Pyrenean-Cantabrian mountain belt was driven by both internal andexternal processes, such as tectonics, erosion and deposition. This alpine belt is made up by thePyrenees and the Cantabrian Mountains, and is characterized by significant lateral variations intotal shortening, structural styles and topography. This thesis aims to better constrain the controlson exhumation and topography development during syn- to post-orogenic times, from the Eoceneto the Pliocene, by focusing on two characteristic parts of the belt: the Southern Central Pyreneesand the Central Cantabrian Mountains. To this purpose, a multi-disciplinary approach isdeveloped, combining low-temperature thermochronology with different numerical mode...