DOIAbstract
The kinetochore is the protein-DNA complex at eukaryotic centromeres that functions as the attachment site for spindle microtubules. In budding yeast, the centromere spans 120 bp, there is a single microtubule per kinetochore, and the entire spindle is composed of 16 kinetochore microtubules plus four interpolar microtubules from each pole. There are >65 different proteins at the kinetochore, organized in at least six core multimeric complexes. A spindle checkpoint network monitors the state of attachment and tension between the microtubule and chromosome. We present a model for the path of DNA in the kinetochore