Mucosal-associated invariant T (MAIT) cells are an abundant class of innate T cells restricted by the MHC I-related molecule MR1. MAIT cells can recognize bacterially-derived metabolic intermediates from the riboflavin pathway presented by MR1 and are postulated to play a role in innate antibacterial immunity through production of cytokines and direct bacterial killing. MR1 tetramers, typically stabilized by the adduct of 5-amino-6-D-ribitylaminour-acil (5-A-RU) and methylglyoxal (MeG), are important tools for the study of MAIT cells. A long-standing problem with 5-A-RU is that it is unstable upon storage. Herein we report an efficient synthetic approach to the HCl salt of this ligand, which has improved stability during storage. We also sh...
T cells discriminate between foreign and host molecules by recognizing distinct microbial molecules,...
MAIT cells are innate-like T lymphocytes that recognize a series of microbial antigens derived from ...
Mucosal-associated invariant T (MAIT) cells are thought to detect microbial antigens presented by th...
Mucosal-associated invariant T (MAIT) cells are an abundant class of innate T cells restricted by th...
Mucosal-associated invariant T (MAIT) cells are an abundant class of innate T cells restricted by th...
Mucosal-associated invariant T cells (MAIT cells) represent a potential therapeutic target as they c...
Mucosal-associated invariant T (MAIT) cells are activated by unstable antigens formed by reactions o...
Mucosal Associated Invariant T (MAIT) cells are restricted by the monomorphic MHC class I-like molec...
The antigen-presenting molecule MR1 presents riboflavin-based metabolites to Mucosal-Associated Inva...
© 2014 Dr. Rangsima ReantragoonMAIT (Mucosal-associated invariant T) cells comprise a subpopulation ...
Mucosal-associated invariant T (MAIT) cells are antibacterial effector T cells that react to pyrimid...
T cells discriminate between foreign and host molecules by recognizing distinct microbial molecules,...
MAIT cells are innate-like T lymphocytes that recognize a series of microbial antigens derived from ...
Mucosal-associated invariant T (MAIT) cells are thought to detect microbial antigens presented by th...
Mucosal-associated invariant T (MAIT) cells are an abundant class of innate T cells restricted by th...
Mucosal-associated invariant T (MAIT) cells are an abundant class of innate T cells restricted by th...
Mucosal-associated invariant T cells (MAIT cells) represent a potential therapeutic target as they c...
Mucosal-associated invariant T (MAIT) cells are activated by unstable antigens formed by reactions o...
Mucosal Associated Invariant T (MAIT) cells are restricted by the monomorphic MHC class I-like molec...
The antigen-presenting molecule MR1 presents riboflavin-based metabolites to Mucosal-Associated Inva...
© 2014 Dr. Rangsima ReantragoonMAIT (Mucosal-associated invariant T) cells comprise a subpopulation ...
Mucosal-associated invariant T (MAIT) cells are antibacterial effector T cells that react to pyrimid...
T cells discriminate between foreign and host molecules by recognizing distinct microbial molecules,...
MAIT cells are innate-like T lymphocytes that recognize a series of microbial antigens derived from ...
Mucosal-associated invariant T (MAIT) cells are thought to detect microbial antigens presented by th...