T cell ontogeny: Organ location of maturing populations as defined by surface antigen markers is similar in neonates and adults
- Haaijman, J.J.
- Micklem, H.S.
- Ledbetter, J.A.
- Dangl, J.L.
- Herzenberg, L.A.
- Herzenberg, L.A.
DOIAbstract
Earlier studies have suggested that splenic T cell populations in nursling mice (<18 d of age) have Lyt cell surface antigens that identify them as less mature than their adult counterparts. Studies presented here, however, demonstrate that the expression of the Thy-1, Lyt-1, Lyt-2, and Lyt-3 T cell antigens is virtually identical in 14-d-old and adult T cell populations even though at 14 d, T cells constitute <10% of the total spleen cell population. Because the expression of these antigens on the immature (cortical) thymocyte population differs substantially from their expression on peripheral T cells, the majority of splenic T cells as judged by these criteria is similar in nurslings and adults. Very few cells in the neonatal thymus 4 h ...
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