Genome-wide association studies linked diacylglycerol kinase eta and iota to mood disorders, including bipolar disorder and schizophrenia, and both genes are expressed throughout the brain. Here, we generated and behaviorally characterized female mice lacking Dgkh alone, Dgki alone, and double Dgkh/Dgki-knockout (dKO) mice. We found that fewer than 30% of newborn pups raised by dKO females survived to weaning, while over 85% of pups survived to weaning when raised by wild-type (WT) females. Poor survival under the care of dKO mothers was unrelated to pup genotype. Moreover, pups from dKO dams survived when fostered by WT dams, suggesting the poor survival rate of dKO-raised litters was related to impaired maternal care by dKO dams. Nest bui...
Valproic acid (VPA) provides a common treatment for both epilepsy and bipolar disorder; however, com...
Several lines of evidence demonstrated that maternal infection during gestation might be an environm...
Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoi...
Diacylglycerol kinases (DGK) control diverse signaling functions. Expression of the iota and eta iso...
BACKGROUND: Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol (DG) to prod...
Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol (DG) to produce phosphat...
Background: Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol to produce p...
<div><h3>Background</h3><p>Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycer...
BACKGROUND: Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol to produce p...
Psychiatric disorder pathogenesis is driven by interactions between multiple genetic and environment...
Summary There has been enormous progress defining the genetic landscape of disease. However, genotyp...
Oxytocin (Oxt) acting through its single receptor subtype, the Oxtr, is important for the coordinati...
AbstractMice completely deficient for Dvl1, one of three mouse homologs of the Drosophila segment po...
We had previously identified the clock gene D-box binding protein (Dbp) as a potential candidate gen...
Oxytocin (Oxt) acting through its single receptor subtype, the Oxtr, is important for the coordinati...
Valproic acid (VPA) provides a common treatment for both epilepsy and bipolar disorder; however, com...
Several lines of evidence demonstrated that maternal infection during gestation might be an environm...
Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoi...
Diacylglycerol kinases (DGK) control diverse signaling functions. Expression of the iota and eta iso...
BACKGROUND: Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol (DG) to prod...
Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol (DG) to produce phosphat...
Background: Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol to produce p...
<div><h3>Background</h3><p>Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycer...
BACKGROUND: Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol to produce p...
Psychiatric disorder pathogenesis is driven by interactions between multiple genetic and environment...
Summary There has been enormous progress defining the genetic landscape of disease. However, genotyp...
Oxytocin (Oxt) acting through its single receptor subtype, the Oxtr, is important for the coordinati...
AbstractMice completely deficient for Dvl1, one of three mouse homologs of the Drosophila segment po...
We had previously identified the clock gene D-box binding protein (Dbp) as a potential candidate gen...
Oxytocin (Oxt) acting through its single receptor subtype, the Oxtr, is important for the coordinati...
Valproic acid (VPA) provides a common treatment for both epilepsy and bipolar disorder; however, com...
Several lines of evidence demonstrated that maternal infection during gestation might be an environm...
Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoi...