Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs
- Guerra-Bubb, J.M.
- Bowers, A.A.
- Smith, W.B.
- Paranal, R.
- Estiu, G.
- Wiest, O.
- Bradner, J.E.
- Williams, R.M.
Publication date
January 2013
DOIAbstract
The synthesis of an isosteric analog of the natural product and HDAC inhibitor largazole is described. The sulfur atom in the thizaole ring of the natural product has been replaced with an oxygen atom, constituting an oxazole ring. The biochemical activity and cytotoxicity of this species is described
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