Calcium metabolism in response to corticotomy-facilitated orthodontic tooth movement in rats

PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.Thesis (MSD) --Boston University, Goldman School of Dental Medicine, 2010 (Department of Orthodontics and Dentofacial Orthopedics).Includes bibliography: leaves 67-74.Orthodontic tooth movement is a non-pathologic inflammatory process that involves the tooth movement by way of alveolar bone modeling. By increasing the inflammatory response, there is thought to be an increase in the rate of tooth movement. Selective alveolar bone decortication in conjunction with orthodontic tooth movement has been shown to increase the rate of bone turnover resulting in both shorter treatment time, and less relapse. PURPOSE: The aim of this study was to analyze calcium metabolism by observing calcium levels and hormonal regulators of calcium levels in the serum in response to orthodontic tooth movement with or without selective alveolar decortication. METHODS: Sprague-Dawley rats (n=153) were divided into 10 groups. Group l was the baseline. Groups 2 to 6 were observed up to 6 weeks and were subdivided into 3 groups: tooth movement only, corticotomy only, and corticotomy plus tooth movement. After 6 weeks of tooth movement, tooth movement was stopped and relapse was observed in the remaining 4 groups for up to 6 weeks. Relapse was observed as a function of time after tooth movement only and after corticotomy facilitated tooth movement. Animals were sacrificed at each time point and histological and serum samples were collected. ELISA’s were performed for the targeted hormones, PTH, calcitonin, and Vitamin D and for serum levels of calcium. [TRUNCATED