WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a large family of WNT ligands and influencing fundamental biological processes. WNT signalling includes the β-catenin canonical pathway and the non-canonical pathways, namely the planar cell polarity and the calcium-dependent pathways. Advances over the past decade have linked non-canonical WNT signalling with key mechanisms of atherosclerosis, including oxidative stress, endothelial dysfunction, macrophage activation and vascular smooth muscle cell phenotype regulation. In addition, non-canonical WNT signalling is involved in crucial aspects of myocardial biology, from fibrosis to hypertrophy and oxidative stress. Importantly, non-canonical WNT signallin...
Abstract Wnt genes encode secreted signalling molecules that control embryonic development including...
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Pharmacology and P...
The wound healing that follows myocardial infarction is a complex process involving multiple mechani...
Wnt signaling pathways play a key role in cardiac development, angiogenesis, and cardiac hypertrophy...
Wnt signaling pathways play a key role in cardiac development, angiogenesis, and cardiac hypertrophy...
Wnt signaling encompasses multiple and complex signaling cascades and is involved in many developmen...
WNT signaling is an elaborate and complex collection of signal transduction pathways mediated by mul...
Wnt signaling plays an essential role during development, but is also activated in diseases as diver...
WNT signaling is an elaborate and complex collection of signal transduction pathways mediated by mul...
Atherosclerosis is a disease of the vascular wall that forms the basis for a large spectrum of patho...
Wnt/beta-catenin signaling pathway plays essential roles in heart development as well as cardiac tis...
Specification and early patterning of the vertebrate heart is dependent on both canonical and non-ca...
Wnt signaling is an important pathway in health and disease and a key regulator of stem cell mainten...
Abstract Wnt genes encode secreted signalling molecules that control embryonic development including...
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Pharmacology and P...
The wound healing that follows myocardial infarction is a complex process involving multiple mechani...
Wnt signaling pathways play a key role in cardiac development, angiogenesis, and cardiac hypertrophy...
Wnt signaling pathways play a key role in cardiac development, angiogenesis, and cardiac hypertrophy...
Wnt signaling encompasses multiple and complex signaling cascades and is involved in many developmen...
WNT signaling is an elaborate and complex collection of signal transduction pathways mediated by mul...
Wnt signaling plays an essential role during development, but is also activated in diseases as diver...
WNT signaling is an elaborate and complex collection of signal transduction pathways mediated by mul...
Atherosclerosis is a disease of the vascular wall that forms the basis for a large spectrum of patho...
Wnt/beta-catenin signaling pathway plays essential roles in heart development as well as cardiac tis...
Specification and early patterning of the vertebrate heart is dependent on both canonical and non-ca...
Wnt signaling is an important pathway in health and disease and a key regulator of stem cell mainten...
Abstract Wnt genes encode secreted signalling molecules that control embryonic development including...
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Pharmacology and P...
The wound healing that follows myocardial infarction is a complex process involving multiple mechani...