Radiation-induced DNA Damage and Repair in Lens Epithelial Cells of both Ptch1(+/–) and Ercc2(+/–) Mutated Mice

Barnard, S. G. R.
McCarron, R.
Mancuso, M.
De Stefano, I.
Pazzaglia, S.
Pawliczek, D.
Dalke, C.
Ainsbury, E. A.

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Publication date

January 2022

DOI

10.1667/RADE-20-00264.1

Publisher

Radiation Research Society

Journal

Radiation Research

Language

English

Abstract

Epidemiological studies suggest an increased incidence and risk of cataract after low-dose (<2 Gy) ionizing radiation exposures. However, the biological mechanism(s) of this process are not fully understood. DNA damage and repair are thought to have a contributing role in radiation-induced cataractogenesis. Recently we have reported an inverse dose-rate effect, as well as the low-dose response, of DNA damage and repair in lens epithelial cells (LECs). Here, we present further initial findings from two mutated strains (Ercc2+/– and Ptch1+/–) of mice, both reportedly susceptible to radiation-induced cataract, and their DNA damage and repair response to low-dose and low-dose-rate gamma rays. Our results support the hypothesis that the lens epi...