Albumin-mediated extracellular zinc speciation drives cellular zinc uptake
- Coverdale, James P. C.
- Van Den Berg, Hugo
- Khazaipoul, Siavash
- Bridgewater, Hannah E.
- Stewart, Alan J.
- Blindauer, Claudia A.
DOIAbstract
The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux
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