This thesis concerns the total synthesis of polyhydroxylated alkaloids of biological interest. (–)-Detoxinine, an unusual amino-acid, (–)-swainsonine, (+)-6-epicastanospermine and (+)-castanospermine, three indolizidines that inhibit glycosidases, have been synthesized from a key intermediate, obtained by allylic oxidation of a known gamma-lactam. The enantiopure gamma-lactam was obtained through asymmetric [2+2] cycloaddition of dichloroketene to a chiral enol ether, an approach developed in our laboratory that provides efficient access to a variety of derivatives. The formation of the indolizidine skeleton through ring-closing metathesis has been used to synthesize the three bicyclic natural products.Ce travail de thèse est consacré à la ...
Les O-glycoconjugués et les dérivés glycosidiques sont des composés naturels impliqués dans de nombr...
La mer et l'océan constituent un réservoir de produits naturels bioactifs d'une immense diversité re...
Dans un contexte industriel où les réactions d'oxydation sont réalisées dans des conditions qui ne s...
This thesis concerns the total synthesis of polyhydroxylated alkaloids of biological interest. (–)-D...
Polyene units constitute an important function from organic compounds and are present in many natura...
This thesis work focuses on the [2+2] asymmetric cycloaddition of ketenes and its application in tot...
The indole ring is one of the most prominent heterocycle in natural products or bioactive compounds....
We prepared salen and dipyrrophenolate iron complexes involving electron rich (tert-butyl and methox...
Ionic liquids, combinations of organic cations and anions, are structured media of several nanometer...
Heparan sulfate (HS) is a linear polysaccharide found in animal tissues at the cell surface or in th...
This PhD thesis deals with the development of new gold(I)-catalyzed reactions involving a hydrogen a...
APN/CD13, a zinc dependent metallo-peptidase ectoenzyme widespread in human tissues is emerging as a...
This manuscript describes the work performed at the Ecole Polytechnique (November 2001 - September 2...
One of the main research directions of modern chemistry is the synthesis and study of new switchable...
The aim of this thesis is to investigate new biobased rigid synthons for the synthesis of polymers w...
Les O-glycoconjugués et les dérivés glycosidiques sont des composés naturels impliqués dans de nombr...
La mer et l'océan constituent un réservoir de produits naturels bioactifs d'une immense diversité re...
Dans un contexte industriel où les réactions d'oxydation sont réalisées dans des conditions qui ne s...
This thesis concerns the total synthesis of polyhydroxylated alkaloids of biological interest. (–)-D...
Polyene units constitute an important function from organic compounds and are present in many natura...
This thesis work focuses on the [2+2] asymmetric cycloaddition of ketenes and its application in tot...
The indole ring is one of the most prominent heterocycle in natural products or bioactive compounds....
We prepared salen and dipyrrophenolate iron complexes involving electron rich (tert-butyl and methox...
Ionic liquids, combinations of organic cations and anions, are structured media of several nanometer...
Heparan sulfate (HS) is a linear polysaccharide found in animal tissues at the cell surface or in th...
This PhD thesis deals with the development of new gold(I)-catalyzed reactions involving a hydrogen a...
APN/CD13, a zinc dependent metallo-peptidase ectoenzyme widespread in human tissues is emerging as a...
This manuscript describes the work performed at the Ecole Polytechnique (November 2001 - September 2...
One of the main research directions of modern chemistry is the synthesis and study of new switchable...
The aim of this thesis is to investigate new biobased rigid synthons for the synthesis of polymers w...
Les O-glycoconjugués et les dérivés glycosidiques sont des composés naturels impliqués dans de nombr...
La mer et l'océan constituent un réservoir de produits naturels bioactifs d'une immense diversité re...
Dans un contexte industriel où les réactions d'oxydation sont réalisées dans des conditions qui ne s...