In this thesis, we address the optimization of aircraft ground operations at airports, focusing on three main optimization problems: the stand allocation, the ground routing between stands and runways, and the sequencing of take-offs and landings.These works result from a close collaboration with Amadeus. Our approaches have been tested and validated with real data from European airports.The stand allocation problem is formulated as a Mixed Integer Program (MIP). We show that finding an allocation plan respecting operational requirements is NP-Complete and we strengthen our model in several directions. We obtain better solutions than the literature withing reasonable computation times for an industrial application.The ground routing problem...