Increased atherosclerosis in a mouse model of glycogen storage disease type 1a
- La Rose, Anouk M.
- Groenen, Anouk G.
- Halmos, Benedek
- Bazioti, Venetia
- Rutten, Martijn G.S.
- Krishnamurthy, Kishore A.
- Koster, Mirjam H.
- Kloosterhuis, Niels J.
- Smit, Marieke
- Havinga, Rick
- Mithieux, Gilles
- Rajas, Fabienne
- Kuipers, Folkert
- Oosterveer, Maaike H.
- Westerterp, Marit
DOIAbstract
Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.</p
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