Although cognitive impairment during aging is usually associated with neuronal alterations, the cerebrovascular system undergoes prominent alterations in aging as well. Using electron microscopy we previously showed a progressive deterioration of the capillary wall in the cerebral cortex of aged rats. In aged rats the capillary basement membrane (BM) is thickened, massive bundles of collagen fibrils are deposited within the BM, and pericytes are degenerating. A compromized cerebral circulation (e.g., in rats with chronic hypertension) is characterized by an increased number of capillary alterations. In autopsy material (gray matter, gyrus cinguli) of carefully diagnosed patient groups (controls, AD, Lewy body disease, MID and demented Lewy ...
The brain, as an intensely active organ, is highly dependent on a sufficient nutrient and oxygen ava...
The aging of the central nervous system and the development of incapacitating neurological diseases ...
Chronic cerebral hypoperfusion has been associated with cognitive decline in aging and Alzheimer's d...
Although cognitive impairment during aging is usually associated with neuronal alterations, the cere...
Although cognitive impairment during aging is usually associated with neuronal alterations, the cere...
Although cognitive impairment during aging is usually associated with neuronal alterations, the cere...
Although cognitive impairment during aging is usually associated with neuronal alterations, the cere...
Alzheimer's disease (AD) patients are often subject to vascular dysfunction besides their specific C...
Alzheimer’s disease (AD) patients are often subject to vascular dysfunction besides their specific C...
De ziekte van Alzheimer is een prominente neurologische aandoening tijdens veroudering die samengaat...
The impact of chronic cerebral hypoperfusion on cognitive function and cerebral capillary morphology...
Chronic cerebral hypoperfusion has been associated with cognitive decline in aging and Alzheimer's d...
The impact of chronic cerebral hypoperfusion on cognitive function and cerebral capillary morphology...
The brain, as an intensely active organ, is highly dependent on a sufficient nutrient and oxygen ava...
The brain, as an intensely active organ, is highly dependent on a sufficient nutrient and oxygen ava...
The aging of the central nervous system and the development of incapacitating neurological diseases ...
Chronic cerebral hypoperfusion has been associated with cognitive decline in aging and Alzheimer's d...
Although cognitive impairment during aging is usually associated with neuronal alterations, the cere...
Although cognitive impairment during aging is usually associated with neuronal alterations, the cere...
Although cognitive impairment during aging is usually associated with neuronal alterations, the cere...
Although cognitive impairment during aging is usually associated with neuronal alterations, the cere...
Alzheimer's disease (AD) patients are often subject to vascular dysfunction besides their specific C...
Alzheimer’s disease (AD) patients are often subject to vascular dysfunction besides their specific C...
De ziekte van Alzheimer is een prominente neurologische aandoening tijdens veroudering die samengaat...
The impact of chronic cerebral hypoperfusion on cognitive function and cerebral capillary morphology...
Chronic cerebral hypoperfusion has been associated with cognitive decline in aging and Alzheimer's d...
The impact of chronic cerebral hypoperfusion on cognitive function and cerebral capillary morphology...
The brain, as an intensely active organ, is highly dependent on a sufficient nutrient and oxygen ava...
The brain, as an intensely active organ, is highly dependent on a sufficient nutrient and oxygen ava...
The aging of the central nervous system and the development of incapacitating neurological diseases ...
Chronic cerebral hypoperfusion has been associated with cognitive decline in aging and Alzheimer's d...