Carbon-fluorine bond formation for the synthesis of aryl fluorides

A selection of carbon-fluorine bond-forming reactions is presented with particular focus on transition-metal-mediated fluorination. A brief summary of conventional fluorination reactions is followed by a discussion of fluorination reactions mediated by palladium and silver. Investigations into the mechanism as well as the conceptual difficulty associated with transition-metal-mediated carbon-fluorine bond formation are presented. 1 Introduction 2 Nucleophilic Fluorination 3 Electrophilic Fluorination 4 Balz-Schiemann Reaction 5 Palladium-Mediated C-X Bond Formation 6 Palladium-Mediated Nucleophilic Fluorination 7 Palladium-Mediated Directed Electrophilic Fluorination 8 Palladium-Mediated Electrophilic Fluorination 9 Silver-Mediated Fluorination 10 Conclusion.