Hepatic differentiation of human-induced pluripotent stem cells (hiPSCs) under flow conditions in a 3D scaffold is expected to be a major step forward for construction of bioartificial livers. The aims of this study were to induce hepatic differentiation of hiPSCs under perfusion conditions and to perform functional comparisons with fresh human precision-cut liver slices (hPCLS), an excellent benchmark for the human liver in vivo. The majority of the mRNA expression of CYP isoenzymes and transporters and the tested CYP activities, Phase II metabolism, and albumin, urea, and bile acid synthesis in the hiPSC-derived cells reached values that overlap those of hPCLS, which indicates a higher degree of hepatic differentiation than observed until...
Hepatocytes derived from human embryonic stem cells (hESCs) or induced pluripotent stem cells (iPSCs...
Tens of millions of patients are affected by liver disease worldwide. Many of these patients can ben...
Pluripotent stem cells can differentiate into many cell types including mature hepatocytes, and can ...
Hepatic differentiation of human-induced pluripotent stem cells (hiPSCs) under flow conditions in a ...
Chronic liver diseases represent a primary worldwide health concern. Liver transplantation is the on...
Human primary hepatocytes (pHEPs) are used as the gold standard model for drug screening and toxicit...
The therapeutic potential of human pluripotent stem (hPS) cells is threatened by the difficulty to h...
The hepatic differentiation of human induced pluripotent stem cells (hiPSC) holds great potential fo...
<div><p>Preparing targeted cells for medical applications from human induced pluripotent stem cells ...
Liver cell therapy and in vitro models require functional human hepatocytes, the sources of which ar...
AbstractMaturation of induced pluripotent stem cells (hiPSCs) to hepatocyte-like cells (HLCs) has be...
Human hepatocytes, suitable for treatment of patients with liver failure, for the creation of bioart...
Background & aimsHepatocyte-like cells (HLCs) differentiated from induced pluripotent stem cells (iP...
Hepatocyte transplantation has been used to treat liver disease. The availability of cells for thes...
AbstractThe establishment of protocols to differentiate human pluripotent stem cells (hPSCs) includi...
Hepatocytes derived from human embryonic stem cells (hESCs) or induced pluripotent stem cells (iPSCs...
Tens of millions of patients are affected by liver disease worldwide. Many of these patients can ben...
Pluripotent stem cells can differentiate into many cell types including mature hepatocytes, and can ...
Hepatic differentiation of human-induced pluripotent stem cells (hiPSCs) under flow conditions in a ...
Chronic liver diseases represent a primary worldwide health concern. Liver transplantation is the on...
Human primary hepatocytes (pHEPs) are used as the gold standard model for drug screening and toxicit...
The therapeutic potential of human pluripotent stem (hPS) cells is threatened by the difficulty to h...
The hepatic differentiation of human induced pluripotent stem cells (hiPSC) holds great potential fo...
<div><p>Preparing targeted cells for medical applications from human induced pluripotent stem cells ...
Liver cell therapy and in vitro models require functional human hepatocytes, the sources of which ar...
AbstractMaturation of induced pluripotent stem cells (hiPSCs) to hepatocyte-like cells (HLCs) has be...
Human hepatocytes, suitable for treatment of patients with liver failure, for the creation of bioart...
Background & aimsHepatocyte-like cells (HLCs) differentiated from induced pluripotent stem cells (iP...
Hepatocyte transplantation has been used to treat liver disease. The availability of cells for thes...
AbstractThe establishment of protocols to differentiate human pluripotent stem cells (hPSCs) includi...
Hepatocytes derived from human embryonic stem cells (hESCs) or induced pluripotent stem cells (iPSCs...
Tens of millions of patients are affected by liver disease worldwide. Many of these patients can ben...
Pluripotent stem cells can differentiate into many cell types including mature hepatocytes, and can ...