Novel genetic loci associated with hippocampal volume
- Hibar, Derrek P.
- Adams, Hieab H. H.
- Jahanshad, Neda
- Chauhan, Ganesh
- Stein, Jason L.
- Hofer, Edith
- Renteria, Miguel E.
- Bis, Joshua C.
- Arias-Vasquez, Alejandro
- Ikram, M. Kamran
- Desrivieres, Sylvane
- Vernooij, Meike W.
- Abramovic, Lucija
- Alhusaini, Saud
- Amin, Najaf
- Andersson, Micael
- Arfanakis, Konstantinos
- Aribisala, Benjamin S.
- Armstrong, Nicola J.
- Athanasiu, Lavinia
- Axelsson, Tomas
- Beecham, Ashley H
- Beiser, Alexa
- Bernard, Manon
- Blanton, Susan H
- Bohlken, Marc M.
- Boks, Marco P.
- Bralten, Janita
- Brickman, Adam M
- Carmichael, Owen
- Chakravarty, M. Mallar
- Chen, Guo-Qiang
- Ching, Christopher R. K.
- Chouraki, Vincent
- Cuellar-Partida, Gabriel
- Crivello, Fabrice
- den Braber, Anouk
- Nhat Trung Doan
- Ehrlich, Stefan
- Giddaluru, Sudheer
- Goldman, Aaron L.
- Gottesman, Rebecca F.
- Grimm, Oliver
- Griswold, Michael E
- Guadalupe, Tulio
- Gutman, Boris A.
- Hass, Johanna
- Haukvik, Unn K.
- Hoehn, David
- Holmes, Avram J.
- Hoogman, Martine
- Janowitz, Deborah
- Jia, Tianye
- Jorgensen, Kjetil N.
- Karbalai, Nazanin
- Kasperaviciute, Dalia
- Kim, Sungeun
- Klein, Marieke
- Kraemer, Bernd
- Lee, Phil H.
- Liewald, David C. M.
- Lopez, Lorna M.
- Luciano, Michelle
- Macare, Christine
- Marquand, Andre F.
- Matarin, Mar
- Mather, Karen A.
- Mattheisen, Manuel
- McKay, David R
- Milaneschi, Yuri
- Maniega, Susana Munoz
- Nho, Kwangsik
- Nugent, Allison C.
- Nyquist, Paul
- Loohuis, Loes M. Olde
- Oosterlaan, Jaap
- Papmeyer, Martina
- Pirpamer, Lukas
- Puetz, Benno
- Ramasamy, Adaikalavan
- Richards, Jennifer S.
- Risacher, Shannon L.
- Roiz-Santianez, Roberto
- Rommelse, Nanda
- Ropele, Stefan
- Rose, Emma J.
- Royle, Natalie A.
- Rundek, Tatjana
- Saemann, Philipp G.
- Saremi, Arvin
- Satizabal, Claudia L.
- Schmaal, Lianne
- Schork, Andrew J.
- Shen, Li
- Shin, Jean
- Shumskaya, Elena
- Smith, Albert V.
- Sprooten, Emma
- Strike, Lachlan T.
- Teumer, Alexander
- Tordesillas-Gutierrez, Diana
- Toro, Roberto
- Trabzuni, Daniah
- Trompet, Stella
- Vaidya, Dhananjay
- van der Grond, Jeroen
- van der Lee, Sven J
- Van der Meer, Dennis
- van Donkelaar, Marjolein M. J.
- van Eijk, Kristel R.
- van Erp, Theo G. M.
- Van Rooij, Daan
- Walton, Esther
- Westlye, Lars T.
- Whelan, Christopher D.
- Windham, Beverly G
- Winkler, Anderson M.
- Wittfeld, Katharina
- Woldehawariat, Girma
- Wolf, Christiane
- Wolfers, Thomas
- Yanek, Lisa R.
- Yang, Jingyun
- Zijdenbos, Alex
- Zwiers, Marcel P.
- Agartz, Ingrid
- Almasy, Laura
- Ames, David
- Amouyel, Philippe
- Andreassen, Ole A.
- Arepalli, Sampath
- Assareh, Amelia A.
- Barral, Sandra
- Bastin, Mark E.
- Becker, Diane M.
- Becker, James T.
- Bennett, David A.
- Blangero, John
- van Bokhoven, Hans
- Boomsma, Dorret I.
- Brodaty, Henry
- Brouwer, Rachel M.
- Brunner, Han G.
- Buckner, Randy L.
- Buitelaar, Jan K.
- Bulayeva, Kazima B.
- Cahn, Wiepke
- Calhoun, Vince D.
- Cannon, Dara M.
- Cavalleri, Gianpiero L.
- Cheng, Ching-Yu
- Cichon, Sven
- Cookson, Mark R.
- Corvin, Aiden
- Crespo-Facorro, Benedicto
- Curran, Joanne E.
- Czisch, Michael
- Dale, Anders M.
- Davies, Gareth E.
- De Craen, Anton J. M.
- Geus, Eco J. C.
- Jager, Philip L. De
- de Zubicaray, Greig I.
- Deary, Ian J.
- Debette, Stephanie
- DeCarli, Charles
- Delanty, Norman
- Depondt, Chantal
- DeStefano, Anita L.
- Dillman, Allissa
- Djurovic, Srdjan
- Donohoe, Gary
- Drevets, Wayne C.
- Duggirala, Ravi
- Dyer, Thomas D.
- Enzinger, Christian
- Erk, Susanne
- Espeseth, Thomas
- Fedko, Iryna O.
- Fernandez, Guillen
- Ferrucci, Luigi
- Fisher, Simon E.
- Fleischman, Debra A
- Ford, Ian
- Fornage, Myriam
- Foroud, Tatiana M.
- Fox, Peter T.
- Francks, Clyde
- Fukunaga, Masaki
- Gibbs, J. Raphael
- Glahn, David C.
- Gollub, Randy L.
- Goring, Harald H. H.
- Green, Robert C.
- Gruber, Oliver
- Gudnason, Vilmundur
- Guelfi, Sebastian
- Haberg, Asta K.
- Hansell, Narelle K.
- Hardy, John
- Hartman, Catharina A.
- Hashimoto, Ryota
- Hegenscheid, Katrin
- Heinz, Andreas
- Le Hellard, Stephanie
- Hernandez, Dena G.
- Heslenfeld, Dirk J.
- Ho, Beng-Choon
- Hoekstra, Pieter J.
- Hoffmann, Wolfgang
- Hofman, Albert
- Holsboer, Florian
- Homuth, Georg
- Hosten, Norbert
- Hottenga, Jouke-Jan
- Huentelman, Matthew
- Pol, Hilleke E. Hulshoff
- Ikeda, Masashi
- Jack, Clifford R.
- Jenkinson, Mark
- Johnson, Robert W.
- Joensson, Erik G.
- Jukema, Wouter J.
- Kahn, Rene S.
- Kanai, Ryota
- Kloszewska, Iwona
- Knopman, David S.
- Kochunov, Peter
- Kwok, John B. J.
- Lawrie, Stephen M.
- Lemaitre, Herve
- Liu, Xinmin
- Longo, Dan L.
- Lopez, Oscar L.
- Lovestone, Simon
- Martinez, Oliver
- Martinot, Jean-Luc
- Mattay, Venkata S.
- McDonald, Colm
- McIntosh, Andrew M.
- McMahon, Francis J.
- McMahon, Katie L.
- Mecocci, Patrizia
- Melle, Ingrid
- Meyer-Lindenberg, Andreas
- Mohnke, Sebastian
- Montgomery, Grant W.
- Morris, Derek W.
- Mosley, Thomas H.
- Muhleisen, Thomas W.
- Mueller-Myhsok, Bertram
- Nalls, Michael A.
- Nauck, Matthias
- Nichols, Thomas E.
- Niessen, Wiro J.
- Nothen, Markus M.
- Nyberg, Lars
- Ohi, Kazutaka
- Olvera, Rene L.
- Ophoff, Roel A.
- Pandolfo, Massimo
- Paus, Tomas
- Pausova, Zdenka
- Penninx, Brenda W. J. H.
- Pike, G. Bruce
- Potkin, Steven G.
- Psaty, Bruce M.
- Reppermund, Simone
- Rietschel, Marcella
- Roffman, Joshua L.
- Romanczuk-Seiferth, Nina
- Rotter, Jerome I.
- Ryten, Mina
- Sacco, Ralph L.
- Sachdev, Perminder S.
- Saykin, Andrew J.
- Schmidt, Reinhold
- Schmidt, Helena
- Schofield, Peter R.
- Sigursson, Sigurdur
- Simmons, Andrew
- Singleton, Andrew
- Sisodiya, Sanjay M.
- Smith, Colin
- Smoller, Jordan W.
- Soininen, Hilkka
- Steen, Vidar M.
- Stott, David J.
- Sussmann, Jessika E.
- Thalamuthu, Anbupalam
- Toga, Arthur W.
- Traynor, Bryan J.
- Troncoso, Juan
- Tsolaki, Magda
- Tzourio, Christophe
- Uitterlinden, Andre G.
- Hernandez, Maria C. Valdes
- Brug, Marcel P. van der
- van der Lugt, Aad
- van der Wee, Nic J. A.
- van Haren, Neeltje E. M.
- van't Ent, Dennis
- Van Tol, Marie-Jose
- Vardarajan, Badri N
- Vellas, Bruno
- Veltman, Dick. J.
- Voelzke, Henry
- Walter, Henrik
- Wardlaw, Joanna M.
- Wassink, Thomas H.
- Weale, Michael E.
- Weinberger, Daniel R.
- Weiner, Michael W.
- Wen, Wei
- Westman, Eric
- White, Tonya
- Wong, Tien Y.
- Wright, Clinton B
- Zielke, Ronald H.
- Zonderman, Alan B.
- Martin, Nicholas G.
- Duijn, Cornelia Mvan
- Wright, Margaret J.
- Longstreth, W. T.
- Schumann, Gunter
- Grabe, Hans J.
- Franke, Barbara
- Launer, Lenore J.
- Medland, Sarah E.
- Seshadri, Sudha
- Thompson, Paul M.
- Ikram, M. Arfan
DOIAbstract
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subicul...
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