HE4 Serum Levels Are Associated with Heart Failure Severity in Patients With Chronic Heart Failure
- Piek, Arnold
- Meijers, Wouter C.
- Schroten, Nicolas F.
- Gansevoort, Ron T.
- de Boer, Rudolf A.
- Sillje, Herman H. W.
DOIAbstract
Background: The novel biomarker human epididymis protein 4 (HE4) shows prognostic value in acute heart failure (HF) patients. We measured HE4 levels in patients with chronic heart failure (CHF) and correlated them to HF severity, kidney function, and HF biomarkers, and determined its predictive value.Methods: Serum HE4 levels in patients (n = 101) with stable CHF with reduced left ventricular ejection fraction (LVEFResults: HE4 levels were higher in CHF compared with control subjects (69.2 pmol/L [interquartile range 55.6-93.8] vs 56.1 pmol/L [46.6-69.0]; PConclusions: HE4 levels are increased in CHF, correlate with HF severity and kidney function, and predict HF outcome.</p
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