Objective:To assess the genetic contribution of TBK1, a gene implicated in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and FTD-ALS, in Belgian FTD and ALS patient cohorts containing a significant part of genetically unresolved patients.Methods:We sequenced TBK1 in a hospital-based cohort of 482 unrelated patients with FTD and FTD-ALS and 147 patients with ALS and an extended Belgian FTD-ALS family DR158. We followed up mutation carriers by segregation studies, transcript and protein expression analysis, and immunohistochemistry.Results:We identified 11 patients carrying a loss-of-function (LOF) mutation resulting in an overall mutation frequency of 1.7% (11/629), 1.1% in patients with FTD (5/460), 3.4% in patients wi...
Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Re...
TANK-binding kinase 1 (TBK1) loss-of-function (LoF) mutations are known to cause frontotemporal deme...
Recently, mutations in the TANK-binding kinase 1 (TBK1) gene were identified as a cause for amyotrop...
Objective:To assess the genetic contribution of TBK1, a gene implicated in amyotrophic lateral scler...
Objective: To assess the genetic contribution of TBK1, a gene implicated in amyotrophic lateral scle...
We investigated the mutation spectrum of the TANK-Binding Kinase 1 (TBK1) gene and its associated ph...
Objective: To evaluate hereditary involvement of TBK1, the quality trapped in amyotrophic lateral sc...
Objective: To assess heritable association of TBK1, the quality trapped in amyotrophic lateral scler...
We investigated the mutation spectrum of the TANK-Binding Kinase 1 (TBK1) gene and its associated ph...
© 2016 The Authors. **Human Mutation published by Wiley Periodicals, Inc. This is an open access art...
Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Re...
TANK-binding kinase 1 (TBK1) loss-of-function (LoF) mutations are known to cause frontotemporal deme...
Recently, mutations in the TANK-binding kinase 1 (TBK1) gene were identified as a cause for amyotrop...
Objective:To assess the genetic contribution of TBK1, a gene implicated in amyotrophic lateral scler...
Objective: To assess the genetic contribution of TBK1, a gene implicated in amyotrophic lateral scle...
We investigated the mutation spectrum of the TANK-Binding Kinase 1 (TBK1) gene and its associated ph...
Objective: To evaluate hereditary involvement of TBK1, the quality trapped in amyotrophic lateral sc...
Objective: To assess heritable association of TBK1, the quality trapped in amyotrophic lateral scler...
We investigated the mutation spectrum of the TANK-Binding Kinase 1 (TBK1) gene and its associated ph...
© 2016 The Authors. **Human Mutation published by Wiley Periodicals, Inc. This is an open access art...
Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Re...
TANK-binding kinase 1 (TBK1) loss-of-function (LoF) mutations are known to cause frontotemporal deme...
Recently, mutations in the TANK-binding kinase 1 (TBK1) gene were identified as a cause for amyotrop...