Neuronal mechanisms of motor learning and motor memory consolidation in healthy old adults

It is controversial whether or not old adults are capable of learning new motor skills and consolidate the performance gains into motor memory in the offline period. The underlying neuronal mechanisms are equally unclear. We determined the magnitude of motor learning and motor memory consolidation in healthy old adults and examined if specific metrics of neuronal excitability measured by magnetic brain stimulation mediate the practice and retention effects. Eleven healthy old adults practiced a wrist extension-flexion visuomotor skill for 20 min (MP, 71.3 years), while a second group onlywatched the templates withoutmovements (attentional control, AC, n=11, 70.5 years). There was 40 % motor learning in MP but none in AC (interaction, p