Identification of Novel Translational Urinary Biomarkers for Acetaminophen-Induced Acute Liver Injury Using Proteomic Profiling in Mice
- van Swelm, Rachel P. L.
- Laarakkers, Coby M. M.
- van der Kuur, Ellen C.
- Morava-Kozicz, Eva
- Wevers, Ron A.
- Augustijn, Kevin D.
- Touw, Daan J.
- Sandel, Maro H.
- Masereeuw, Rosalinde
- Russel, Frans G. M.
DOIAbstract
Drug-induced liver injury (DILI) is the leading cause of acute liver failure. Currently, no adequate predictive biomarkers for DILI are available. This study describes a translational approach using proteomic profiling for the identification of urinary proteins related to acute liver injury induced by acetaminophen (APAP). Mice were given a single intraperitoneal dose of APAP (0-350 mg/kg bw) followed by 24 h urine collection. Doses of ≥275 mg/kg bw APAP resulted in hepatic centrilobular necrosis and significantly elevated plasma alanine aminotransferase (ALT) values (
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