Mechanisms of cellular resistance to cisplatin

Hospers, G. A. P.
Mulder, N. H.
de Vries, E. G. E.

Publication date

January 1988

DOI

Abstract

Treatment of cancer patients often fails because of the resistance in the tumor to chemotherapeutic drugs. A better understanding of mechanisms which are active in resistant cells might lead to measures to circumvent the resistance. This review deals with the mechanisms of action of cisplatin (CDDP) and the various causes for CDDP resistance in the tumor cells. Also, possibilities to circumvent CDDP resistancein vitro andin vivo are presented

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Mechanisms of cellular resistance to cisplatin

Abstract

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Mechanisms of cellular resistance to cisplatin

Abstract

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